Search International and National Patent Collections

1. (WO2017149538) ANTIBODIES SPECIFIC TO HUMAN POLIOVIRUS RECEPTOR (PVR)

Pub. No.:    WO/2017/149538    International Application No.:    PCT/IL2017/050256
Publication Date: Sat Sep 09 01:59:59 CEST 2017 International Filing Date: Wed Mar 01 00:59:59 CET 2017
IPC: C07K 16/28
A61P 35/00
Applicants: YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.
UNIVERSITY OF RIJEKA FACULTY OF MEDICINE
Inventors: MANDELBOIM Ofer
KAYNAN, Noa S.
TSUKERMAN, Pinchas
JONJIC, Stipan
Title: ANTIBODIES SPECIFIC TO HUMAN POLIOVIRUS RECEPTOR (PVR)
Abstract:
The present invention provides monoclonal antibodies that recognize polio virus receptor (PVR) and inhibit its binding to T cell immunoreceptor with Ig and ITIM domains (TIGIT). The present invention further provides pharmaceutical compositions comprising the antibodies and methods for their use in cancer immunotherapy, treating infections and in diagnosis.