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1. (WO2017149502) METHOD FOR REDUCING THE RESISTANCE TO ANTICANCER DRUGS, RADIORESISTANCE AND CANCER STEM CELLS FORMATION AND METASTATIC PHENOTYPE
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Pub. No.: WO/2017/149502 International Application No.: PCT/IB2017/051243
Publication Date: 08.09.2017 International Filing Date: 03.03.2017
IPC:
A61K 31/122 (2006.01) ,A61K 31/353 (2006.01) ,A61K 45/06 (2006.01) ,A61P 35/00 (2006.01) ,A61P 35/04 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
12
Ketones
122
having the oxygen atom directly attached to a ring, e.g. quinones, vitamin K1, anthralin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
335
having oxygen as the only ring hetero atom, e.g. fungichromin
35
having six-membered rings with one oxygen as the only ring hetero atom
352
condensed with carbocyclic rings, e.g. cannabinols, methantheline
353
3,4-Dihydrobenzopyrans, e.g. chroman, catechin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06
Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
04
specific for metastasis
Applicants:
BIOUP SAGL [CH/CH]; Via G. Calgari 2 6900 Lugano, CH
Inventors:
MANCINI, Alessando; CH
Agent:
ERRICO, Michela; IT
BIGGI, Cristina; IT
ROSSETTI, Elena; IT
Priority Data:
10201600002232703.03.2016IT
Title (EN) METHOD FOR REDUCING THE RESISTANCE TO ANTICANCER DRUGS, RADIORESISTANCE AND CANCER STEM CELLS FORMATION AND METASTATIC PHENOTYPE
(FR) PROCÉDÉ DE RÉDUCTION DE LA RÉSISTANCE AUX MÉDICAMENTS ANTICANCÉREUX, DE LA RADIORÉSISTANCE, DE LA FORMATION DES CELLULES SOUCHES CANCÉREUSES ET DU PHÉNOTYPE MÉTASTATIQUE
Abstract:
(EN) The present invention relates to the use of systems involved in ROS generation (reactive oxygen species) to reduce resistance to chemotherapy and radiation therapy, reduce cancer stem cell formation and inhibit the metastatic phenotype; the subject matter of the invention further relates to inhibitors of ROS generation serving to reduce resistance to chemotherapy and radiation therapy and inhibit cancer stem cell formation and inhibit the metastatic phenotype.
(FR) La présente invention concerne l'utilisation de systèmes impliqués dans la génération de DRO (dérivés réactifs de l'oxygène) pour réduire la résistance à la chimiothérapie et à la radiothérapie, réduire la formation des cellules souches cancéreuses et inhiber le phénotype métastatique; l'invention concerne en outre des inhibiteurs de la génération de DRO servant à réduire la résistance à la chimiothérapie et à la radiothérapie et à inhiber la formation des cellules souches cancéreuses et du phénotype métastatique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: Italian (IT)