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1. (WO2017149469) HETEROCYCLIC COMPOUNDS USEFUL AS IDO AND/OR TDO MODULATORS
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Pub. No.: WO/2017/149469 International Application No.: PCT/IB2017/051190
Publication Date: 08.09.2017 International Filing Date: 01.03.2017
IPC:
C07D 487/04 (2006.01) ,A61K 31/519 (2006.01) ,A61P 25/00 (2006.01) ,A61P 29/00 (2006.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
EMCURE PHARMACEUTICALS LIMITED [IN/IN]; Emcure House, T-184, M.I.D.C., Bhosari Pune 411026, IN
Inventors:
GURJAR, Mukund Keshav; IN
ROYCHOWDHURY, Abhijit; IN
KHALADKAR, Tushar Pandurang; IN
MAGAR, Dhananjay Ravindra; IN
KOTHALKAR, Nishant Chandrakant; IN
GULLAPALLI, Srinivas; IN
KULATHINGAL, Jayanarayan; IN
LEKKALA, Rammohan Reddy; IN
Priority Data:
IN 20162100754103.03.2016IN
IN 20162102330707.07.2016IN
Title (EN) HETEROCYCLIC COMPOUNDS USEFUL AS IDO AND/OR TDO MODULATORS
(FR) COMPOSÉS HÉTÉROCYCLIQUES UTILES EN TANT QUE MODULATEURS DE L'IDO ET/OU DE LA TDO
Abstract:
(EN) Present invention relates to novel heterocyclic compounds as indoleamine 2,3- dioxygenase (IDO) and/or tryptophan 2,3-dioxygenase (TDO) modulators. Compounds of the present invention inhibit tryptophan degradation by modulating IDO and/or TDO. Formula (I) The invention further relates to the process of their preparation, pharmaceutical composition and their use in modulating the activity of indoleamine 2,3-dioxygenase (IDO) and/or tryptophan 2,3- dioxygenase (TDO). The compounds of the invention can be used alone or in combination for the treatment of conditions that benefits from the inhibition of tryptophan degradation.
(FR) La présente invention concerne de nouveaux composés hétérocycliques en tant que modulateurs de l'indoleamine 2,3-dioxygénase (IDO) et/ou de la tryptophane 2,3-dioxygénase (TDO). Les composés de la présente invention inhibent la dégradation du tryptophane par la modulation de l'IDO et/ou de la TDO. Formule (I). L'invention concerne en outre le procédé de préparation de ces composés, une composition pharmaceutique ainsi que l'utilisation de ceux-ci pour moduler l'activité de l'indoléamine 2,3-dioxygénase (IDO) et/ou de la tryptophane 2,3-dioxygénase (TDO). Les composés de l'invention peuvent être utilisés seuls ou en combinaison pour le traitement d'états pathologiques qui bénéficient d'une inhibition de la dégradation du tryptophane.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)