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1. (WO2017149450) METHOD TO ASSESS CHROMATOGRAPHIC COLUMN LIFE TIME

Pub. No.:    WO/2017/149450    International Application No.:    PCT/IB2017/051164
Publication Date: Sat Sep 09 01:59:59 CEST 2017 International Filing Date: Wed Mar 01 00:59:59 CET 2017
IPC: B01D 15/08
B01J 19/00
B08B 3/08
Applicants: DR. REDDYS LABORATORIES
Inventors: SHARMA, Ketan
DHUNDI, Ritesh M
SRIVASTAVA, Shitanshu
Title: METHOD TO ASSESS CHROMATOGRAPHIC COLUMN LIFE TIME
Abstract:
The present invention relates to the field of preparative chromatography. The invention provides a rapid method to assess the chromatographic column lifetime during a preparative scale chromatography. The method specifically measures the difference in the column back pressures obtained at two different flow rates, during the cleaning step of a chromatographic process, to assess the re-usability or lifetime of the resin/matrix.