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1. (WO2017149331) N-BROMOTAURINE SOLUTIONS AND EMULSIONS AGAINST ABNORMAL CELLS
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Pub. No.: WO/2017/149331 International Application No.: PCT/GR2017/000007
Publication Date: 08.09.2017 International Filing Date: 17.02.2017
IPC:
A61K 31/185 (2006.01) ,A61P 17/06 (2006.01) ,A61P 17/00 (2006.01) ,A61P 31/22 (2006.01) ,A61K 9/00 (2006.01) ,A61K 47/36 (2006.01) ,A61K 9/107 (2006.01) ,A61K 47/44 (2017.01) ,A61K 9/70 (2006.01) ,A61L 15/00 (2006.01) ,C07C 309/14 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17
Drugs for dermatological disorders
06
Antipsoriatics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17
Drugs for dermatological disorders
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
20
for DNA viruses
22
for herpes viruses
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
36
Polysaccharides; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
107
Emulsions
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
44
Oils, fats or waxes according to more than one of groups A61K47/02-A61K47/42109
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
70
Web, sheet or filament bases
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
15
Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
309
Sulfonic acids; Halides, esters, or anhydrides thereof
01
Sulfonic acids
02
having sulfo groups bound to acyclic carbon atoms
03
of an acyclic saturated carbon skeleton
13
containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
14
containing amino groups bound to the carbon skeleton
Applicants:
NASCO AD BIOTECHNOLOGY LABORATORY [GR/GR]; 11 Sachtouri Str. GR-185 36 Pireus, GR
Inventors:
KYRIAKOPOULOS, Antonios; GR
Priority Data:
2016010007201.03.2016GR
Title (EN) N-BROMOTAURINE SOLUTIONS AND EMULSIONS AGAINST ABNORMAL CELLS
(FR) SOLUTIONS ET ÉMULSIONS DE N-BROMOTAURINE DIRIGÉES CONTRE DES CELLULES ANORMALES
Abstract:
(EN) A method of producing aqueous solutions of N-bromotaurine (Taurine Bromanine, NBrT) with excess taurine (in a ratio 1:5) with later addition of NaOBr. Emulsions of these solutions with Stable Produced Olive Oil (S.P.O.O.) for use against hyper-proliferative and abnormally differentiating cells of human and mammalian origin. In addition, due to the hyper-proliferation of keratinocytes in psoriatic skin, said aqueous solutions and emulsions containing NBrT and excess taurine, and S.P.O.O. are useful against the lesions of psoriasis. Said solutions, when applied on cells in vitro, provide maximization of NBrT anti-proliferative properties on abnormally differentiating and hyper-proliferating cells of human and mammalian origin by restoring NBrT anti-proliferative activity in a solution, whilst leaving unaffected the proliferation of normally dividing human fibroblasts. The use of NBrT / taurine solutions in psoriasis optimally comprises the simultaneous use of S.P.O.O. by concurrent mixing to make an emulsion. S.P.O.O. is derived from the physical refinement of olive oil and is mixed with N-bromotaurine / taurine solutions to produce an active emulsion, and thereafter to derive ointments, creams, lotions, as medicinal preparations to treat psoriasis and Herpes Zoster dermatoses. Beneficially, when S.P.O.O. is utilized to make an emulsion with NBrT / taurine aqueous solutions and applied on psoriatic lesions coupled with NaOBr later addition this shortens to half the time period for psoriasis lesions regression and minimizes side effects on dermal tissue as compared to the NBrT aqueous solution application on psoriatic lesions.
(FR) La présente invention concerne un procédé de production de solutions aqueuses de N-bromotaurine (Taurine Bromamine, NBrT) avec un excès de taurine (dans un rapport de 1:5) avec une addition ultérieure de NaOBr. L'invention concerne également des émulsions de ces solutions avec un produit d'huile d'olive stable (S.P.O.O.) destinées à être utilisées contre des cellules hyper-prolifératives et se différenciant de manière anormale d'origine humaine et de mammifère. De plus, en raison de l'hyper-prolifération des kératinocytes dans une peau atteinte de psoriasis, lesdites solutions et émulsions aqueuses contenant la NBrT et un excès de taurine et du S.P.O.O., sont utiles contre les lésions du psoriasis. Lesdites solutions, lorsqu'elles sont appliquées sur des cellules in vitro, confèrent une maximisation des propriétés anti-prolifératives de la NBrT sur les cellules hyper-prolifératives et se différenciant de manière anormale d'origine humaine et de mammifère par la restauration de l'activité anti-proliférative de la NBrT dans une solution, tout en laissant intacte la prolifération des fibroblastes humains se divisant normalement. L'utilisation de solutions de NBrT/taurine dans des cas de psoriasis comprend idéalement l'utilisation simultanée de S.P.O.O. en les mélangeant simultanément pour préparer une émulsion. La S.P.O.O. est dérivée du raffinage physique de l'huile d'olive et est mélangée avec des solutions de N-bromotaurine/taurine pour produire une émulsion active, et puis utilisée pour obtenir des onguents, des crèmes, des lotions, en tant que préparations médicinales pour traiter le psoriasis et des dermatoses dues à l'herpès zoster. Avantageusement, lorsque la S.P.O.O. est utilisée pour préparer une émulsion avec des solutions aqueuses de NBrT/taurine et est appliquée sur des lésions psoriasiques en association avec une addition ultérieure de NaOBr, celle-ci raccourcit de moitié la période de régression des lésions du psoriasis et réduit au minimum les effets secondaires sur les tissus dermiques par comparaison à l'application d'une solution aqueuse de NBrT sur des lésions psoriasiques.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)