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1. (WO2017149306) COMBINATION THERAPY

Pub. No.:    WO/2017/149306    International Application No.:    PCT/GB2017/050553
Publication Date: Sat Sep 09 01:59:59 CEST 2017 International Filing Date: Fri Mar 03 00:59:59 CET 2017
IPC: A61K 38/18
A61K 39/395
A61P 9/00
A61P 9/12
A61P 11/00
Applicants: CAMBRIDGE ENTERPRISE LIMITED
Inventors: MORRELL, Nicholas W
UPTON, Paul D
Title: COMBINATION THERAPY
Abstract:
The present invention concerns inter alia a pharmaceutical composition comprising: (1) a polypeptide selected from bone morphogenetic protein 10 (BMP10) and a bone morphogenetic protein 9 (BMP9) variant lacking osteogenic activity; and (2) a TNFα inhibitor. Also envisaged according to the invention are medical uses and methods for treating a vascular disease or a respiratory disease in a patient by means of the pharmaceutical composition.