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1. (WO2017149296) 3D PRINTING OF A CELLULARISED SCAFFOLD

Pub. No.:    WO/2017/149296    International Application No.:    PCT/GB2017/050541
Publication Date: Sat Sep 09 01:59:59 CEST 2017 International Filing Date: Wed Mar 01 00:59:59 CET 2017
IPC: C12N 5/077
C12N 5/00
C12M 3/02
C12M 1/26
Applicants: OXFORD UNIVERSITY INNOVATION LIMITED
Inventors: BAYLEY, Hagan
OLOF, Sam
GRAHAM, Alexander D
BURKE, Madeline
ARMSTRONG, James
PERRIMAN, Adam
NICHOLSON, James
SZELE, Francis
Title: 3D PRINTING OF A CELLULARISED SCAFFOLD
Abstract:
The present invention relates to a process for producing a droplet assembly, which droplet assembly comprises a plurality of droplets, wherein each of said droplets comprises: an aqueous medium comprising a hydrogel compound; and one or more biological cells disposed in the aqueous medium, which process comprises: generating, in a bulk hydrophobic medium, a plurality of droplets, wherein each of said droplets comprises: an aqueous medium comprising a hydrogel compound; and one or more biological cells disposed in the aqueous medium. The invention also relates to a droplet assembly comprising a plurality of droplets, wherein each of said droplets comprises: (i) an aqueous medium comprising a hydrogel compound; (ii) one or more biological cells disposed in the aqueous medium; and (iii) an outer layer of amphipathic molecules around the surface of the aqueous medium, wherein at least one droplet in the droplet assembly contacts at least one other droplet in the droplet assembly forming a layer of amphipathic molecules as an interface between contacting droplets.