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1. (WO2017149188) MUTATION OF CANDIDA ALBICANS AND USE IN TREATMENT AGAINST CANDIDIASIS

Pub. No.:    WO/2017/149188    International Application No.:    PCT/ES2017/070118
Publication Date: Sat Sep 09 01:59:59 CEST 2017 International Filing Date: Fri Mar 03 00:59:59 CET 2017
IPC: C12N 1/15
A61K 39/00
Applicants: UNIVERSITAT DE VALÈNCIA
UNIVERSIDAD DE CASTILLA LA MANCHA
UNIVERSIDAD DE MURCIA
FUNDACIÓN PARA LA INVESTIGACIÓN DEL HOSPITAL UNIVERSITARIO Y POLITECNICO LA FE
Inventors: VALENTÍN GÓMEZ, Eulogio
MAICAS PRIETO, Sergi
MICÓ GARCÍA, Miguel
MARTÍNEZ-PEREZ ROMERO, Ana Isabel
DE GROOT, Petrus Wilhemus Johannes
MARTÍNEZ-ESPARZA ALVARGONZÁLEZ, María
PEMÁN GARCÍA, Francisco Javier
Title: MUTATION OF CANDIDA ALBICANS AND USE IN TREATMENT AGAINST CANDIDIASIS
Abstract:
The invention relates to mutations of Candida albicans lacking functional copies of their PIR1 gene, preferably via deletion in all the copies thereof, as well as a method for producing same. Said mutations are attenuated strains that do not cause candidiasis symptoms, but do provide protection against same when injected into an animal prior to infection with an infectious strain. The invention comprises the use of said mutations to trigger a protective response against candidiasis, or specifically as live attenuated vaccines, in particular against disseminated candidiasis.