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1. (WO2017149052) PROCESS AND INTERMEDIATES FOR THE PRODUCTION OF 17(20)-ENE B-SECO STEROIDS
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Pub. No.: WO/2017/149052 International Application No.: PCT/EP2017/054838
Publication Date: 08.09.2017 International Filing Date: 01.03.2017
IPC:
C07J 1/00 (2006.01) ,C07C 215/42 (2006.01) ,C07C 225/12 (2006.01) ,C07J 21/00 (2006.01) ,C07J 51/00 (2006.01) ,C07F 7/18 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
J
STEROIDS
1
Normal steroids containing carbon, hydrogen, halogen, or oxygen, not substituted in position 17 beta by a carbon atom, e.g. oestrane, androstane
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
215
Compounds containing amino and hydroxy groups bound to the same carbon skeleton
42
having amino groups or hydroxy groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
225
Compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly-bound oxygen atoms not being part of a -CHO group, e.g. amino ketones
02
having amino groups bound to acyclic carbon atoms of the carbon skeleton
04
the carbon skeleton being saturated
08
and containing rings
12
with doubly-bound oxygen atoms bound to carbon atoms being part of rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
J
STEROIDS
21
Normal steroids containing carbon, hydrogen, halogen, or oxygen, having an oxygen-containing hetero ring spiro-condensed with the cyclopenta[a]hydrophenanthrene skeleton
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
J
STEROIDS
51
Normal steroids with unmodified cyclopenta[a]hydrophenanthrene skeleton not provided for in groups C07J1/-C07J43/151
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
7
Compounds containing elements of the 4th Group of the Periodic System
02
Silicon compounds
08
Compounds having one or more C-Si linkages
18
Compounds having one or more C-Si linkages as well as one or more C-O-Si linkages
Applicants:
PATHEON AUSTRIA GMBH & CO KG [AT/AT]; St.-Peter-Straße 25 4020 Linz, AT
Inventors:
YIANNIKOUROS, George Petros; US
KALARITIS, Panos; US
AREFYEV, Denis Viktorovich; US
Agent:
WOHLER, Christian; Life Technologies GmbH Frankfurter Str. 129b 64293 Darmstadt, DE
Priority Data:
62/302,41002.03.2016US
Title (EN) PROCESS AND INTERMEDIATES FOR THE PRODUCTION OF 17(20)-ENE B-SECO STEROIDS
(FR) PROCÉDÉ ET INTERMÉDIAIRES DESTINÉS À LA PRODUCTION DE STÉROÏDES 17(20)-ENE B-SECO
Abstract:
(EN) The invention pertains to a process for producing a compound of formula (11) wherein R7 and R8 are each independently selected from H, halogen, alkyl, aryl, or alkylaryl, R42 is H or a protective group, R43 is H or R3, wherein R3 is a protective group, by contacting a compound of formula (10) with an olefination reagent, wherein compound of formula (10) comprises a counter acid X1 when R42 = H and R43 = H.
(FR) La présente invention concerne un procédé de production d'un composé de formule (11), R7 et R8 étant chacun indépendamment sélectionnés parmi H, un groupe halogéno, alkyle, aryle, ou alkylaryle, R42 est H ou un groupe protecteur, R43 est H ou R3, R3 étant un groupe protecteur, par mise en contact d'un composé de formule (10) avec un réactif d'oléfination, le composé de formule (10) comprenant un contre-acide X1 lorsque R42 = H et R43 = H.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)