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1. (WO2017149018) METHODS AND KITS FOR PREDICTING THE RISK OF RELAPSE IN PATIENTS SUFFERING FROM IDIOPATHIC NEPHROTIC SYNDROME

Pub. No.:    WO/2017/149018    International Application No.:    PCT/EP2017/054781
Publication Date: Sat Sep 09 01:59:59 CEST 2017 International Filing Date: Thu Mar 02 00:59:59 CET 2017
IPC: C12Q 1/68
G01N 33/569
Applicants: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)
UNIVERSITÉ PARIS-EST CRÉTEIL VAL DE MARNE
ASSISTANCE PUBLIQUE-HÔPITAUX DE PARIS (APHP)
Inventors: SAHALI, Djillali
PAWLAK, André
OLLERO, Mario
Title: METHODS AND KITS FOR PREDICTING THE RISK OF RELAPSE IN PATIENTS SUFFERING FROM IDIOPATHIC NEPHROTIC SYNDROME
Abstract:
The present invention relates to methods and kits for predicting the risk of relapse in patients suffering from idiopathic nephrotic syndrome. No test exists for mechanistically classifying idiopathic and secondary nor for predicting the risk of relapse, with consequent non-specific and toxic treatment regimes. In particular, the present invention relates to a method of predicting the risk of relapse in a patient suffering from idiopathic nephrotic syndrome i) comprising quantifying the level of FoxP3 positive cells and the level of CMIP positive cells in a blood sample obtained from the patient, ii) comparing the level quantified at step i) with their respective predetermined reference values and iii) concluding that the patient is at risk of relapse when the level of FoxP3 positive cells is lower than its predetermined reference value and the level of CMIP positive cells is higher than its predetermined reference value.