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1. (WO2017148964) NEW TRIFLUOROMETHYLPROPANAMIDE DERIVATIVES AS HTRA1 INHIBITORS

Pub. No.:    WO/2017/148964    International Application No.:    PCT/EP2017/054677
Publication Date: Sat Sep 09 01:59:59 CEST 2017 International Filing Date: Thu Mar 02 00:59:59 CET 2017
IPC: C07K 5/062
C07K 5/083
C07K 5/078
C07K 5/065
C07K 5/068
C07K 5/072
A61K 31/4402
A61P 27/00
Applicants: F. HOFFMANN-LA ROCHE AG
HOFFMANN-LA ROCHE INC.
Inventors: HORNSPERGER, Benoit
IACONE, Roberto
MAERKI, Hans P.
MOHR, Peter
REUTLINGER, Michael
Title: NEW TRIFLUOROMETHYLPROPANAMIDE DERIVATIVES AS HTRA1 INHIBITORS
Abstract:
The invention provides serine protease HTRA1 inhibiting compounds having the general formula (I) wherein R 2, R 3, R 4, R 5, R 6, R 7, R 3, R 8, R 10, R 11and R 23 are as described herein. These compounds are suitable for the treatment of ocular diseases such as age-related macular degeneration and others.