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1. (WO2017148928) MEANS AND METHODS FOR TREATING HERPESVIRUS INFECTION

Pub. No.:    WO/2017/148928    International Application No.:    PCT/EP2017/054615
Publication Date: Sat Sep 09 01:59:59 CEST 2017 International Filing Date: Wed Mar 01 00:59:59 CET 2017
IPC: A61K 39/245
C12N 7/00
Applicants: HELMHOLTZ ZENTRUM MÜNCHEN - DEUTSCHES FORSCHUNGSZENTRUM FÜR GESUNDHEIT UND UMWELT (GMBH)
Inventors: HAMMERSCHMIDT, Wolfgang
ZEIDLER, Reinhard
PICH, Dagmar
Title: MEANS AND METHODS FOR TREATING HERPESVIRUS INFECTION
Abstract:
The present invention provides herpesviruses, such as EBV, which lack at least one viral miRNA. Such herpesviruses lacking at least one viral miRNA are advantageously not capable of packaging their genome into the capsid, thereby producing HVLPs, which are substantially free of their herpesvirus genome or the nucleic acid molecule encoding the proteinaceous part of the HVLP and viral miRNA. Such HVLPs may be used as vaccine.