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1. (WO2017148927) ABUSE-DETERRENT PHARMACEUTICAL COMPOSITION
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Pub. No.: WO/2017/148927 International Application No.: PCT/EP2017/054614
Publication Date: 08.09.2017 International Filing Date: 28.02.2017
Chapter 2 Demand Filed: 25.08.2017
IPC:
A61K 9/06 (2006.01) ,A61K 47/36 (2006.01) ,A61K 31/00 (2006.01) ,C12N 9/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
06
Ointments; Bases therefor
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
36
Polysaccharides; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
Applicants:
G.L. PHARMA GMBH [AT/AT]; Schlossplatz 1 8502 Lannach, AT
Inventors:
GÜBITZ, Georg; AT
GREIMEL, Katrin; AT
BRANDAUER, Martin; AT
HUBER, Daniela; AT
BLEYMAIER, Klaus; AT
KROUTIL, Wolfgang; AT
LECHNER, Doris; AT
WACHTER, Christof; AT
WAGNER, Harald; AT
WINKLER, Heimo; AT
Agent:
SONN & PARTNER Patentanwälte; Riemergasse 14 1010 Vienna, AT
Priority Data:
16157798.629.02.2016EP
Title (EN) ABUSE-DETERRENT PHARMACEUTICAL COMPOSITION
(FR) COMPOSITION PHARMACEUTIQUE ANTI-ABUS
Abstract:
(EN) Disclosed is an abuse-deterrent pharmaceutical composition comprising a drug with an enzyme-reactive functional group, wherein the drug has an abuse potential, and an enzyme capable of reacting with the enzyme-reactive functional group (a drug-processing enzyme), wherein the drug with the enzyme-reactive functional group is contained in the pharmaceutical composition in a storage stable, enzyme-reactive state and under conditions wherein no enzymatic activity acts on the drug.
(FR) L'invention concerne une composition pharmaceutique anti-abus comprenant un médicament possédant un groupe fonctionnel réactif aux enzymes, le médicament pouvant faire l'objet d'une consommation abusive, et une enzyme capable de réagir avec le groupe fonctionnel réactif aux enzymes (une enzyme de traitement du médicament), le médicament possédant le groupe fonctionnel réactif aux enzymes étant contenu dans la composition pharmaceutique dans un état stable au stockage et réactif aux enzymes et dans des conditions dans lesquelles aucune activité enzymatique n'affecte le médicament.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)