Search International and National Patent Collections

1. (WO2017148862) POLYMERASE VARIANTS

Pub. No.:    WO/2017/148862    International Application No.:    PCT/EP2017/054502
Publication Date: Sat Sep 09 01:59:59 CEST 2017 International Filing Date: Tue Feb 28 00:59:59 CET 2017
IPC: C12N 9/12
Applicants: GENIA TECHNOLOGIES, INC.
F. HOFFMANN-LA ROCHE AG
Inventors: AYER, Aruna
DALAL, Dhruti
SARVABHOWMAN, Preethi
Title: POLYMERASE VARIANTS
Abstract:
The present disclosure provides variant Pol6 polymerase polypeptides, compositions comprising the Pol6 variant polypeptides, and methods for using the variant Pol6 polypeptides for determining the sequencing of nucleic acids, for example, by nanopore sequencing. The variant Pol6 polymerases possess decreased rates of dissociation of template from the polymerase-template complex, which result in increased processivity relative to the parental Pol6 polypeptides from which they are derived.