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1. (WO2017148861) EXONUCLEASE DEFICIENT POLYMERASES

Pub. No.:    WO/2017/148861    International Application No.:    PCT/EP2017/054501
Publication Date: Sat Sep 09 01:59:59 CEST 2017 International Filing Date: Tue Feb 28 00:59:59 CET 2017
IPC: C12N 9/12
Applicants: GENIA TECHNOLOGIES, INC.
F. HOFFMANN-LA ROCHE AG
Inventors: AYER, Aruna
BIBILLO, Arkadiusz
DALAL, Dhruti
SARVABHOWMAN, Preethi
LEDERMAN, Ilya
THAI, Eileen
Title: EXONUCLEASE DEFICIENT POLYMERASES
Abstract:
Described herein are polymerase variants that are exonuclease deficient. Some variants retain the strand displacement capability comparable to the wild-type or parental polymerase. Some variants have a strand displacement capability that is improved relative to the wild-type or parental polymerase. The variants may have an extension rate that is greater than the wild-type or parental polymerase. The variants may have a waiting time that is less than the wild-type or parental polymerase.