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1. (WO2017148455) IODINATED ANALOGS OF CHOLINE, METHODS OF PREPARATION THEREOF, AND USE THEREOF AS MEDICAMENTS

Pub. No.:    WO/2017/148455    International Application No.:    PCT/CZ2017/050010
Publication Date: Sat Sep 09 01:59:59 CEST 2017 International Filing Date: Wed Mar 01 00:59:59 CET 2017
IPC: C07D 333/28
C07C 211/62
C07D 453/02
C07D 295/073
C07D 295/084
C07D 213/65
A61K 31/452
A61P 9/12
A61P 25/22
A61P 35/00
A61P 37/00
Applicants: UNIVERZITA PALACKEHO V OLOMOUCI
Inventors: SVEC, Pavel
HRUBY, Martin
KUCKA, Jan
SEDLACEK, Ondrej
PETRIK, Milos
NOVY, Zbynek
HAJDUCH, Marian
Title: IODINATED ANALOGS OF CHOLINE, METHODS OF PREPARATION THEREOF, AND USE THEREOF AS MEDICAMENTS
Abstract:
The invention relates to iodinated aromatic choline analogs of general formula wherein at least one R is iodine; the quaternary ammonium group comprises a hydroxyl substituent, and further substituent are as defined in the claims. The compounds of the invention can be used in medicine as imaging agents and therapeutics, in particular in oncologic, inflammatory and neurological disorders.