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1. (WO2017148454) PHOTOACTIVATABLE NANOPARTICLES FOR PHOTODYNAMIC APPLICATIONS, METHOD OF PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND USE THEREOF

Pub. No.:    WO/2017/148454    International Application No.:    PCT/CZ2017/050008
Publication Date: Sat Sep 09 01:59:59 CEST 2017 International Filing Date: Sat Feb 25 00:59:59 CET 2017
IPC: A61K 41/00
A61K 9/51
A61P 35/00
Applicants: USTAV MAKROMOLEKULARNI CHEMIE AV CR, V.V.I.
VYSOKA SKOLA CHEMICKO-TECHNOLOGICKA V PRAZE
Inventors: HRUBY, Martin
BREZANIOVA, Ingrid
KRAL, Vladimir
Title: PHOTOACTIVATABLE NANOPARTICLES FOR PHOTODYNAMIC APPLICATIONS, METHOD OF PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND USE THEREOF
Abstract:
The present invention relates to photoactivatable nanoparticles for photodynamic applications containing a photosensitizer, a (C8 to C22) fatty alcohol and a polymeric surfactant, preferably poly(ethylene oxide) monomethyl ether-block-poly(ε-caprolactone), whereas the size of the nanoparticle is in the range of from 1 to 1000 nm, and the core of the nanoparticle is solid at the temperature of 4 °C, and liquid at the temperature around 39 °C. The present invention further relates to a method of preparation of the photoactivatable nanoparticle, a pharmaceutical composition containing it, and use thereof.