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1. (WO2017148440) PTERIDINONE DERIVATIVE SERVING AS FLT3 INHIBITOR, AND USES
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Pub. No.: WO/2017/148440 International Application No.: PCT/CN2017/075628
Publication Date: 08.09.2017 International Filing Date: 03.03.2017
IPC:
C07D 475/00 (2006.01) ,A61K 31/519 (2006.01) ,A61P 35/00 (2006.01) ,A61P 37/02 (2006.01) ,A61P 17/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
475
Heterocyclic compounds containing pteridine ring systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
02
Immunomodulators
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17
Drugs for dermatological disorders
Applicants:
华东理工大学 EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY [CN/CN]; 中国上海市 徐汇区梅陇路130号 No. 130 Meilong Road, Xuhui District Shanghai 200237, CN
Inventors:
李洪林 LI, Honglin; CN
徐玉芳 XU, Yufang; CN
陈卓 CHEN, Zhuo; CN
孙德恒 SUN, Deheng; CN
吕剑昆 LV, Jiankun; CN
赵振江 ZHAO, Zhenjiang; CN
宋文琳 SONG, Wenlin; CN
周伟 ZHOU, Wei; CN
杨宇 YANG, Yu; CN
Agent:
上海一平知识产权代理有限公司 XU & PARTNERS,LLC.; 中国上海市 普陀区真北路958号天地科技广场1号楼106室 Room No.106, Building No.1, Universal High-Tech Plaza,958 Zhen Bei Road, Putuo District Shanghai 200333, CN
Priority Data:
201610125930.904.03.2016CN
Title (EN) PTERIDINONE DERIVATIVE SERVING AS FLT3 INHIBITOR, AND USES
(FR) DÉRIVÉ DE PTÉRIDINONE SERVANT D'INHIBITEUR DE FLT3, ET UTILISATIONS
(ZH) 作为FLT3抑制剂的蝶啶酮衍生物及应用
Abstract:
(EN) The present invention relates to a pteridinone derivative serving as an FLT3 inhibitor, and uses thereof. Specifically, the present invention relates to a compound represented by formula (I), a pharmaceutical composition containing the compound represented by formula (I), and uses of the compound in the preparation of drugs for treating diseases mediated by FLT3 or for inhibiting the FLT3: (I).
(FR) La présente invention concerne un dérivé de ptéridinone utilisé comme inhibiteur de FLT3 et ses utilisations. Plus particulièrement, la présente invention concerne un composé représenté par la formule (I), une composition pharmaceutique contenant le composé de formule (I) et des utilisations du composé dans la préparation de médicaments pour le traitement de maladies médiées par FLT3 ou pour l'inhibition du FLT3: (I).
(ZH) 本发明涉及作为FLT3抑制剂的蝶啶酮衍生物及其应用。具体而言,本发明涉及下式I所示的化合物、含有下式I化合物的药物组合物及所述化合物在制备治疗FLT3介导的疾病或抑制FLT3的药物中的用途:(I)。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)