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1. (WO2017148431) OVARIAN CANCER SPECIFICALLY TARGETED BIODEGRADABLE AMPHIPHILIC POLYMER, POLYMER VESICLE PREPARED THEREBY AND USE THEREOF
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Pub. No.: WO/2017/148431 International Application No.: PCT/CN2017/075529
Publication Date: 08.09.2017 International Filing Date: 03.03.2017
IPC:
C08G 64/18 (2006.01) ,C08G 64/30 (2006.01) ,A61K 9/51 (2006.01) ,A61K 47/34 (2017.01) ,A61K 47/42 (2017.01) ,A61P 35/00 (2006.01)
C CHEMISTRY; METALLURGY
08
ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
G
MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
64
Macromolecular compounds obtained by reactions forming a carbonic ester link in the main chain of the macromolecule
18
Block or graft polymers
C CHEMISTRY; METALLURGY
08
ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
G
MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
64
Macromolecular compounds obtained by reactions forming a carbonic ester link in the main chain of the macromolecule
20
General preparatory processes
30
using carbonates
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
48
Preparations in capsules, e.g. of gelatin, of chocolate
50
Microcapsules
51
Nanocapsules
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
34
Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
42
Proteins; Polypeptides; Degradation products thereof; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
博瑞生物医药(苏州)股份有限公司 BRIGHTGENE BIO-MEDICAL TECHNOLOGY CO., LTD. [CN/CN]; 中国江苏省苏州市 苏州工业园区星湖街218号纳米科技园C25栋 Building C25, No. 218 Xinghu Street, BioBay, Suzhou Industrial Park Suzhou, Jiangsu 215123, CN
Inventors:
孟凤华 MENG, Fenghua; CN
邹艳 ZOU, Yan; CN
钟志远 ZHONG, Zhiyuan; CN
袁建栋 YUAN, Jiandong; CN
Agent:
北京三聚阳光知识产权代理有限公司 SUNSHINE INTELLECTUAL PROPERTY INTERNATIONAL CO., LTD; 中国北京市 海淀区海淀南路甲21号中关村知识产权大厦A座5层503 Room 503, Floor 5, Tower A No. 21, A, Haidian South Road Zhongguancun Intellectual Property Building, Haidian District Beijing 100080, CN
Priority Data:
201610123977.104.03.2016CN
Title (EN) OVARIAN CANCER SPECIFICALLY TARGETED BIODEGRADABLE AMPHIPHILIC POLYMER, POLYMER VESICLE PREPARED THEREBY AND USE THEREOF
(FR) POLYMÈRE AMPHIPHILE BIODÉGRADABLE CIBLANT DE MANIÈRE SPÉCIFIQUE LE CANCER DE L'OVAIRE, VÉSICULE DE POLYMÈRE PRÉPARÉE AVEC CE POLYMÈRE ET UTILISATION ASSOCIÉE
(ZH) 卵巢癌特异靶向的生物可降解双亲性聚合物、由其制备的聚合物囊泡及应用
Abstract:
(EN) Provided are an ovarian cancer specifically targeted biodegradable amphiphilic polymer, a polymer vesicle prepared thereby and use thereof. The biodegradable amphiphilic polymer is prepared by a polymer containing dithiocarbonate monomer bonded with targeting molecules. The polymer vesicle prepared with the biodegradable amphiphilic polymer can crosslink spontaneously without adding an extra crosslinker, and the crosslink has a reduction activity and hence can be used in drug controlled-release systems, and contributes to the clinical use and production of nano-drugs.
(FR) L'invention concerne un polymère amphiphile biodégradable ciblant de manière spécifique le cancer de l'ovaire, une vésicule de polymère préparée avec ce polymère et une utilisation associée. Le polymère amphiphile biodégradable est préparé avec un polymère contenant un monomère de dithiocarbonate lié à des molécules de ciblage. La vésicule de polymère préparée avec le polymère amphiphile biodégradable peut se réticuler spontanément sans ajouter d'agent de réticulation supplémentaire, et la réticulation a une activité de réduction et peut donc être utilisée dans des systèmes à libération pharmacologique contrôlée, et contribue à l'utilisation clinique et à la production de nano-médicaments.
(ZH) 提供一种卵巢癌特异靶向的生物可降解双亲性聚合物、由其制备的聚合物囊泡及其应用。所述生物可降解双亲性聚合物由含双硫碳酸酯单体的聚合物键合靶向分子制得。由所述生物可降解双亲性聚合物制备的聚合物囊泡可自行交联而无需外加交联剂,且该交联具有原敏感性,因而其可用于药物控释体系,有利于纳米药物临床应用生产。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)