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|1. (WO2017148417) 2,3-EPOXY SUCCINYL DERIVATIVE, PREPARATION METHOD THEREFOR, AND USES THEREOF|
|Applicants:||INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA
|Title:||2,3-EPOXY SUCCINYL DERIVATIVE, PREPARATION METHOD THEREFOR, AND USES THEREOF|
Disclosed in the present invention are a 2,3-epoxy succinyl derivative, a preparation method therefor, and uses thereof. Specifically, disclosed in the present invention are a compound represented by formula (1), a raceme thereof, an optical isomer thereof, a solvate thereof or a pharmaceutical acceptable salt thereof. The compound in the present invention has good inhibitory activity and/or selectivity on cathepsins and especially on cathepsin B, and can be used for treating multiple kinds of diseases related to cathepsins, such as osteoporosis, rheumatoid arthritis and osteoarthritis related to cathepsin K, Ebola virus infection, degenerative diseases and autoimmune diseases related to cathepsins L and S, especially tumor diseases related to cathepsin B, such as stomach cancer, cervical cancer, lung cancer, breast cancer, prostate cancer, bladder cancer, colon cancer, glioma and melanoma.