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1. (WO2017148406) PYRIMIDINE SEVEN-MEMBERED-RING COMPOUNDS, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND USES THEREOF

Pub. No.:    WO/2017/148406    International Application No.:    PCT/CN2017/075416
Publication Date: Sat Sep 09 01:59:59 CEST 2017 International Filing Date: Fri Mar 03 00:59:59 CET 2017
IPC: C07D 495/14
C07D 487/04
C07D 491/147
A61K 31/554
A61K 31/5513
A61K 31/553
A61P 37/06
A61P 25/00
A61P 9/10
A61P 1/00
A61P 9/00
A61P 17/00
Applicants: ANHUI NEW STAR PHARMACEUTICAL DEVELOPMENT CO., LTD
安徽省新星药物开发有限责任公司
Inventors: DENG, Xianming
邓贤明
ZHOU, Dawang
周大旺
CHEN, Lanfen
陈兰芬
HE, Zhixiang
何志祥
FAN, Fuqin
樊福钦
Title: PYRIMIDINE SEVEN-MEMBERED-RING COMPOUNDS, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF, AND USES THEREOF
Abstract:
The present invention relates to compounds (I) capable of inhibiting the Mst1/2 protein kinase activity, a preparation method therefor, a pharmaceutical composition comprising the compounds, and uses of the compounds and the pharmaceutical composition comprising the compounds in the preparation of drugs for prompting repair and regeneration of tissues and organs, prompting stem cell proliferation and adult cell dedifferentiation, immunosuppression, and preventing or treating diseases related to nervous disorders in organisms, and local ischemia diseases.