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1. (WO2017148359) PHARMACEUTICAL COMPOSITION COMPRISING PYRROLO-FUSED SIX-MEMBERED HETEROCYCLIC COMPOUND

Pub. No.:    WO/2017/148359    International Application No.:    PCT/CN2017/075111
Publication Date: Sat Sep 09 01:59:59 CEST 2017 International Filing Date: Wed Mar 01 00:59:59 CET 2017
IPC: A61K 31/437
A61K 47/26
A61P 35/00
A61P 35/04
Applicants: JIANGSU HENGRUI MEDICINE CO., LTD.
江苏恒瑞医药股份有限公司
Inventors: LU, Yun
卢韵
ZHANG, Xinhua
张新华
WANG, Chenyang
王晨阳
LIU, Tonghui
刘同辉
Title: PHARMACEUTICAL COMPOSITION COMPRISING PYRROLO-FUSED SIX-MEMBERED HETEROCYCLIC COMPOUND
Abstract:
The present invention provides a pharmaceutical composition comprising a pyrrolo-fused six-membered heterocyclic compound or a pharmaceutically acceptable salt of the compound. Specifically, the invention provides a pharmaceutical composition comprising 5-(2-diethylamino-ethyl)-2-(5-fluoro-2-oxo-1,2-dihydro-indol-3-ylidene-methyl)-3-methyl-1,5,6,7-tetrahydro-pyrrolo[3,2-c]pyridin-4-one or a pharmaceutically acceptable salt thereof, and at least one water soluble filler. The pharmaceutical composition of the invention features rapid dissolution and good stability.