Search International and National Patent Collections

1. (WO2017148358) TUMOUR THERAPEUTIC MONOCLONAL ANTIBODY NANO-CAPSULE AND PREPARATION METHOD AND USE THEREOF

Pub. No.:    WO/2017/148358    International Application No.:    PCT/CN2017/075103
Publication Date: Sat Sep 09 01:59:59 CEST 2017 International Filing Date: Wed Mar 01 00:59:59 CET 2017
IPC: A61K 9/51
A61K 47/32
A61K 39/395
A61P 35/00
Applicants: TIANJIN NANUO BIO-TECHNOLOGY CO., LTD.
天津纳诺生物科技有限公司
Inventors: YUAN, Xubo
原续波
KANG, Chunsheng
康春生
LU, Yunfeng
卢云峰
Title: TUMOUR THERAPEUTIC MONOCLONAL ANTIBODY NANO-CAPSULE AND PREPARATION METHOD AND USE THEREOF
Abstract:
Disclosed is a tumour therapeutic monoclonal antibody nano-capsule, i.e. a nano-capsule which is prepared by the polymerization of poly 2-methacryloyloxyethyl phosphorylcholine and nimotuzumab, has a round and smooth surface, a uniform particle size and a tumour targeting delivery effect. It has inhibitory effect on proliferation of a tumour, in particular glioma and gastric tumours. The preparation method is taking 0.1-100 mg nimotuzumab solution, adding a monomer having a carbon-carbon double bond, a crosslinker and an initiator respectively according to the molar ratio of the nimotuzumab solution and the monomer having a carbon-carbon double bond, the crosslinker and the initiator of 1:100-1:100000, 1:100-1:10000, 1:100-1:10000 and obtaining the desired product by the method of in situ polymerization.