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|1. (WO2017148358) TUMOUR THERAPEUTIC MONOCLONAL ANTIBODY NANO-CAPSULE AND PREPARATION METHOD AND USE THEREOF|
|Applicants:||TIANJIN NANUO BIO-TECHNOLOGY CO., LTD.
|Title:||TUMOUR THERAPEUTIC MONOCLONAL ANTIBODY NANO-CAPSULE AND PREPARATION METHOD AND USE THEREOF|
Disclosed is a tumour therapeutic monoclonal antibody nano-capsule, i.e. a nano-capsule which is prepared by the polymerization of poly 2-methacryloyloxyethyl phosphorylcholine and nimotuzumab, has a round and smooth surface, a uniform particle size and a tumour targeting delivery effect. It has inhibitory effect on proliferation of a tumour, in particular glioma and gastric tumours. The preparation method is taking 0.1-100 mg nimotuzumab solution, adding a monomer having a carbon-carbon double bond, a crosslinker and an initiator respectively according to the molar ratio of the nimotuzumab solution and the monomer having a carbon-carbon double bond, the crosslinker and the initiator of 1:100-1:100000, 1:100-1:10000, 1:100-1:10000 and obtaining the desired product by the method of in situ polymerization.