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|1. (WO2017148318) SUBSTITUTED ACRYLAMIDE COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF|
|Applicants:||SHENZHEN TARGETRX, INC.
|Title:||SUBSTITUTED ACRYLAMIDE COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF|
Disclosed are a substituted acrylamide compound and a pharmaceutical composition thereof, the substituted acrylamide compound being a compound of a formula (I), or a crystalline form, pharmaceutically acceptable salt, prodrug, stereoisomer, hydrate, or solvate thereof. The compound of the present invention can inhibit activity of a histone deacetylase (HDAC) and also has improved pharmacodynamic/pharmacokinetic properties; the compound has high applicability, is safe to use, and can be used for the preparation of a pharmaceutical composition for the treatment of HDAC-mediated diseases, thereby having great market potential.