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1. (WO2017148318) SUBSTITUTED ACRYLAMIDE COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF

Pub. No.:    WO/2017/148318    International Application No.:    PCT/CN2017/074372
Publication Date: Sat Sep 09 01:59:59 CEST 2017 International Filing Date: Thu Feb 23 00:59:59 CET 2017
IPC: C07C 311/21
A61K 31/18
A61P 35/00
A61P 17/06
A61P 19/08
A61P 11/00
A61P 9/10
Applicants: SHENZHEN TARGETRX, INC.
深圳市塔吉瑞生物医药有限公司
Inventors: WANG, Yihan
王义汉
JIN, Jian
金剑
Title: SUBSTITUTED ACRYLAMIDE COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF
Abstract:
Disclosed are a substituted acrylamide compound and a pharmaceutical composition thereof, the substituted acrylamide compound being a compound of a formula (I), or a crystalline form, pharmaceutically acceptable salt, prodrug, stereoisomer, hydrate, or solvate thereof. The compound of the present invention can inhibit activity of a histone deacetylase (HDAC) and also has improved pharmacodynamic/pharmacokinetic properties; the compound has high applicability, is safe to use, and can be used for the preparation of a pharmaceutical composition for the treatment of HDAC-mediated diseases, thereby having great market potential.