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1. (WO2017148290) SUBSTITUTED ADENINE COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF
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Pub. No.: WO/2017/148290 International Application No.: PCT/CN2017/074135
Publication Date: 08.09.2017 International Filing Date: 20.02.2017
IPC:
C07F 9/6561 (2006.01) ,A61K 31/675 (2006.01) ,A61P 31/18 (2006.01) ,A61P 31/12 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9
Compounds containing elements of the 5th Group of the Periodic System
02
Phosphorus compounds
547
Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
6561
containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
66
Phosphorus compounds
675
having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
14
for RNA viruses
18
for HIV
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31
Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12
Antivirals
Applicants:
深圳市塔吉瑞生物医药有限公司 SHENZHEN TARGETRX, INC. [CN/CN]; 中国广东省深圳市 南山区科苑路15号科兴科学园A1栋301 Room 301, Building A1 Kexing Science Park, No.15 of Keyuan Road, Nanshan District Shenzhen, Guangdong 518057, CN
Inventors:
王义汉 WANG, Yihan; CN
赵九洋 ZHAO, Jiuyang; CN
Priority Data:
201610114361.801.03.2016CN
Title (EN) SUBSTITUTED ADENINE COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF
(FR) COMPOSÉ D'ADÉNINE SUBSTITUÉE ET COMPOSITION PHARMACEUTIQUE CORRESPONDANTE
(ZH) 一种取代的腺嘌呤化合物及其药物组合物
Abstract:
(EN) Disclosed are a substituted adenine compound and a pharmaceutical composition thereof, the substituted adenine compound being a compound of a formula (I), or a crystalline form, pharmaceutically acceptable salt, prodrug, stereoisomer, hydrate, or solvate thereof. The compound of the present invention can inhibit activity of a nucleoside reverse transcriptase and also has improved pharmacodynamic/pharmacokinetic properties; the compound has high applicability, is safe to use, and can be used for the preparation of a pharmaceutical composition for the treatment of viral infection-associated diseases, thereby having great market potential.
(FR) L'invention concerne un composé d'adénine substituée et une composition pharmaceutique correspondante, le composé d'adénine substituée étant un composé de formule (I), ou une forme cristalline, un sel, promédicament, stéréoisomère, hydrate ou solvate associé pharmaceutiquement acceptable. Le composé selon la présente invention peut inhiber l'activité d'une transcriptase inverse de nucléoside et présente également de meilleures propriétés pharmacodynamiques/pharmacocinétiques ; le composé a une grande applicabilité, il est sans danger et peut être utilisé pour la préparation d'une composition pharmaceutique destinée au traitement des maladies associées aux infections virales, ce qui lui donne de grandes possibilités commerciales.
(ZH) 一种取代的腺嘌呤化合物及其药物组合物,所述取代的腺嘌呤化合物如为式(I)所示的化合物,或其晶型、药学上可接受的盐、前药、立体异构体、水合物或溶剂化合物。所述化合物可抑制核苷类逆转录酶活性,同时具有更好药效学/药代动力学性能,化合物的适用性好、安全性高,可用于制备治疗病毒感染相关的疾病,具有良好的市场开发前景。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)