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1. (WO2017147958) USE OF OXYGEN-CONTAINING HYDROCARBON DERIVATIVE AS POLYMYXIN SYNERGIST
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2017/147958 International Application No.: PCT/CN2016/077921
Publication Date: 08.09.2017 International Filing Date: 30.03.2016
IPC:
A61K 31/045 (2006.01) ,A61K 31/185 (2006.01) ,A61K 38/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
045
Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
185
Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
Applicants:
广州英赛特生物技术有限公司 GUANGZHOU INSIGHTER BIOTECHNOLOGY CO., LTD. [CN/CN]; 中国广东省广州市 萝岗区广州高新技术产业开发区科学城掬泉路3号广州国际企业孵化器D区415号 No. 415, Building D, Guangzhou International Business Incubator No. 3,Juquan Road, Guangzhou Science Park Guangzhou Hi-Tech Industrial Development, Luogang District Guangzhou, Guangdong 510663, CN
Inventors:
彭险峰 PENG, Xianfeng; CN
覃宗华 QIN, Zonghua; CN
Agent:
广州科粤专利商标代理有限公司 GUANGZHOU KEYUE I. P. LAW OFFICE; 中国广东省广州市 越秀区先烈中路100号大院23-1栋616室 Room 616, 6/F, Building 23-1 No. 100, Xianlie Central Road, Yuexiu District Guangzhou, Guangdong 510070, CN
Priority Data:
201610124829.104.03.2016CN
Title (EN) USE OF OXYGEN-CONTAINING HYDROCARBON DERIVATIVE AS POLYMYXIN SYNERGIST
(FR) UTILISATION D’UN DÉRIVÉ D’HYDROCARBURE COMPORTANT DE L’OXYGÈNE EN TANT QUE SYNERGISTE DE POLYMYXINE
(ZH) 含氧碳氢衍生物作为多粘菌素的协同增效剂的应用
Abstract:
(EN) Disclosed are a pharmaceutical composition comprising a polymyxin synergist and the use thereof. The oxygen-containing hydrocarbon derivative containing 4 to 18 carbon atoms includes a fatty alcohol, a fatty acid and a fatty acid glyceride and serves as a polymyxin synergist, in particular as a synergist for a strain sensitive to the polymyxin inhibiting effect and as a drug-resistance reversal agent for polymyxin. Also disclosed is a pharmaceutical composition of the polymyxin synergist. The pharmaceutical composition is further used for preparing a drug and an animal feed additive for the treatment of a disease caused by polymyxin-sensitive bacterial infection or drug-resistant bacterial infection, and provides a more effective application space for the use of polymyxin, and is of great importance in application in the fields of pharmaceutics and animal breeding.
(FR) La présente invention concerne une composition pharmaceutique comportant un synergiste de polymyxine et l'utilisation associée. Le dérivé d'hydrocarbure comportant de l'oxygène comportant de 4 à 18 atomes de carbone comprend un alcool gras, un acide gras et un glycéride d'acide gras et sert de synergiste de polymyxine, il fait notamment office de synergiste pour une souche sensible à l'effet inhibiteur de la polymyxine et d'agent de suppression de la résistance aux médicaments pour la polymyxine. L'invention concerne également une composition pharmaceutique du synergiste de polymyxine. La composition pharmaceutique est en outre utilisée en vue de préparer un médicament et un additif alimentaire pour animaux en vue du traitement d'une maladie provoquée par une infection bactérienne sensible à la polymyxine ou une infection bactérienne résistante aux médicaments, et offre un espace d'application plus efficace en vue de l'utilisation de polymyxine, et présente une grande importance dans l'application liée aux domaines de la pharmacie et de l'élevage d'animaux.
(ZH) 一种包含多粘菌素协同增效剂的药用组合物及其用途。含有4-18个碳原子的含氧碳氢衍生物包括脂肪醇、脂肪酸和脂肪酸甘油酯作为多粘菌素增效剂,特别是作为多粘菌素抑制敏感菌株的协同增效剂和多粘菌素的耐药性逆转剂,并公开了该多粘菌素增效剂的药用组合物,进一步还将该药用组合物应用于制备治疗多粘菌素敏感菌或耐药菌感染所致疾病的药物以及动物用饲料添加剂中,为多粘菌素的应用提供了更为有效的应用空间,在制药领域和动物养殖领域具有十分重要的应用价值。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)