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1. (WO2017147941) RECOMBINANT MESENCHYMAL STEM CELL AND PREPARATION METHOD AND USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2017/147941 International Application No.: PCT/CN2016/075812
Publication Date: 08.09.2017 International Filing Date: 07.03.2016
IPC:
C12N 5/10 (2006.01) ,A61K 35/28 (2015.01) ,A61K 38/20 (2006.01) ,A61K 48/00 (2006.01) ,A61P 29/00 (2006.01) ,A61P 3/00 (2006.01) ,A61P 37/02 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
10
Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
28
Marrow; Spleen
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
19
Cytokines; Lymphokines; Interferons
20
Interleukins
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
02
Immunomodulators
Applicants:
深圳爱生再生医学科技有限公司 SHEN ZHEN ISTEM REGENERATIVE MEDICINE SCI-TECH. CO., LTD [CN/CN]; 中国广东省深圳市 南山区高新区南环路29号留学生创业大厦15楼02号 Room 02, Floor 15, Overseas Chinese Scholars Venture Building, No.29 South Circle Road High-Tech Zone, Nanshan District Shenzhen, Guangdong 518057, CN
Inventors:
曾宪卓 ZENG, Xianzhuo; CN
Agent:
广州华进联合专利商标代理有限公司 ADVANCE CHINA IP LAW OFFICE; 中国广东省广州市 天河区花城大道85号3901房 Room 3901, No. 85 Huacheng Avenue Tianhe District Guangzhou, Guangdong 510623, CN
Priority Data:
201610119603.202.03.2016CN
Title (EN) RECOMBINANT MESENCHYMAL STEM CELL AND PREPARATION METHOD AND USE THEREOF
(FR) CELLULE SOUCHE MÉSENCHYMATEUSE RECOMBINÉE, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION
(ZH) 重组间充质干细胞及其制备方法和应用
Abstract:
(EN) Provided are a recombinant mesenchymal stem cell and a preparation method therefor. The recombinant mesenchymal stem cell is obtained via the transfection of a first messenger RNA for expressing P-selectin glycoprotein ligand-1, a second messenger RNA for expressing sialyl Lewis oligosaccharide-X antigen, and a third messenger RNA for expressing interleukin-10 in the mesenchymal stem cell.
(FR) La présente invention concerne une cellule souche mésenchymateuse recombinée et un procédé de préparation associé. La cellule souche mésenchymateuse recombinée est obtenue par transfection d'un premier ARN messager pour exprimer le ligand-1 de la glycoprotéine de P-sélectine, un deuxième ARN messager pour exprimer un antigène d'oligosaccharide de sialyl Lewis-X, et un troisième ARN messager pour exprimer l'interleukine-10 dans la cellule souche mésenchymateuse.
(ZH) 提供了一种重组间充质干细胞及其制备方法。通过在间充质干细胞中转染用于表达P选择素糖蛋白配体-1的第一信使RNA、用于表达唾液酸化路易斯寡糖-X抗原的第二信使RNA和用于表达白介素-10的第三信使RNA,得到重组间充质干细胞。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)