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1. (WO2017147893) POSACONAZOLE, COMPOSITION, INTERMEDIATE, PREPARATION METHOD THEREFOR, AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2017/147893 International Application No.: PCT/CN2016/075594
Publication Date: 08.09.2017 International Filing Date: 04.03.2016
IPC:
C07D 263/22 (2006.01) ,C07D 263/26 (2006.01) ,C07D 413/06 (2006.01) ,C07D 307/24 (2006.01) ,C07D 307/12 (2006.01) ,C07D 405/06 (2006.01) ,C07D 405/14 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
263
Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
02
not condensed with other rings
08
having one double bond between ring members or between a ring member and a non-ring member
16
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
18
Oxygen atoms
20
attached in position 2
22
with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to other ring carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
263
Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
02
not condensed with other rings
08
having one double bond between ring members or between a ring member and a non-ring member
16
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
18
Oxygen atoms
20
attached in position 2
26
with hetero atoms or acyl radicals directly attached to the ring nitrogen atom
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
413
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
02
containing two hetero rings
06
linked by a carbon chain containing only aliphatic carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
307
Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
02
not condensed with other rings
04
having no double bonds between ring members or between ring members and non-ring members
18
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
24
Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
307
Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
02
not condensed with other rings
04
having no double bonds between ring members or between ring members and non-ring members
10
with substituted hydrocarbon radicals attached to ring carbon atoms
12
Radicals substituted by oxygen atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
405
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02
containing two hetero rings
06
linked by a carbon chain containing only aliphatic carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
405
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
14
containing three or more hetero rings
Applicants:
浙江奥翔药业股份有限公司 ZHEJIANG AUSUN PHARMACEUTICAL CO., LTD. [CN/CN]; 中国浙江省临海市 化学原料药基地临海园区东海第四大道五号 No.5, Donghai 4th Avenue, Linhai Zone, Zhejiang Chemical Materials Base Linhai, Zhejiang 317016, CN
Inventors:
郑志国 ZHENG, Zhiguo; CN
Agent:
中科专利商标代理有限责任公司 CHINA SCIENCE PATENT & TRADEMARK AGENT LTD.; 中国北京市 海淀区西三环北路87号4-1105室 Suite 4-1105, No. 87, West 3rd Ring North Rd., Haidian District Beijing 100089, CN
Priority Data:
Title (EN) POSACONAZOLE, COMPOSITION, INTERMEDIATE, PREPARATION METHOD THEREFOR, AND USES THEREOF
(FR) POSACONAZOLE, COMPOSITION, INTERMÉDIAIRE, SON PROCÉDÉ DE PRÉPARATION, ET SES UTILISATIONS
(ZH) 泊沙康唑、组合物、中间体及其制备方法和用途
Abstract:
(EN) The present invention relates to a compound represented by formula (III), R being selected from C1-C4 alkyls, substituted or unsubstituted phenyl or substituted or unsubstituted benzyl, and being preferably selected from isopropyl; and two Ars capable of being the same or different, respectively and separately selected from substituted or unsubstituted aryl, and being preferably selected from substituted or unsubstituted phenyl, such as methoxyphenyl. The compound is preferably in a solid form.
(FR) La présente invention décrit un composé représenté par la formule III, R étant sélectionné parmi les groupes alkyle en C1 à C4, le groupe phényle substitué ou non substitué ou benzyle substitué ou non substitué, et étant sélectionné de préférence parmi le groupe isopropyle ; et deux Ar pouvant être identiques ou différents, respectivement et séparément sélectionnés parmi le groupe aryle substitué ou non substitué, et étant sélectionnés de préférence parmi le groupe phényle substitué ou non substitué, tel qu’un groupe méthoxyphényle. Le composé se présente de préférence sous une forme solide.
(ZH) 本发明涉及式III的化合物,其中,R选自C1-C4烷基、取代的或未被取代的苯基、取代的或未被取代的苄基,优选异丙基;两个Ar可以相同或不同,各自独立地选自取代的或未被取代的芳基,优选取代的或未被取代的苯基,如对甲氧苯基等,所述化合物优选为固体形式。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)