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1. (WO2017147649) METHODS OF TREATMENT
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Pub. No.: WO/2017/147649 International Application No.: PCT/AU2017/050173
Publication Date: 08.09.2017 International Filing Date: 28.02.2017
IPC:
A61K 35/28 (2015.01) ,A61P 19/02 (2006.01) ,A61B 17/56 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
28
Marrow; Spleen
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19
Drugs for skeletal disorders
02
for joint disorders, e.g. arthritis, arthrosis
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
B
DIAGNOSIS; SURGERY; IDENTIFICATION
17
Surgical instruments, devices or methods, e.g. tourniquets
56
Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
Applicants:
MAGELLAN STEM CELLS PTY LTD [AU/AU]; C/- Minter Ellison 525 Collins Street Melbourne, Victoria 3000, AU
Inventors:
HANSEN, Peter; AU
FREITAG, Julien; AU
SHAH, Kiran; AU
Agent:
FB RICE; Level 14, 90 Collins St Melbourne, Victoria 3000, AU
Priority Data:
201690074329.02.2016AU
Title (EN) METHODS OF TREATMENT
(FR) MÉTHODES DE TRAITEMENT
Abstract:
(EN) The present invention relates to method of treating a human subject suffering from joint degeneration. The method is based on local administration of human mesenchymal stem cells (e.g., autologous human mesenchymal stem cells) according to a specific therapeutically effective administration regimen that minimizes moderate and severe adverse events. The invention also relates to a method of treating a human subject suffering from joint degeneration, where the method includes performing abrasion osteoplasty on an affected joint followed by local administration to the affected joint of a therapeutically effective number of human mesenchymal stem cells.
(FR) La présente invention concerne une méthode de traitement d'un sujet humain souffrant de dégénérescence articulaire. La méthode est fondée sur l'administration locale de cellules souches mésenchymateuses humaines (par exemple, des cellules souches mésenchymateuses humaines autologues) selon un régime spécifique d'administration thérapeutiquement efficace qui réduit à un minimum les effets secondaires modérés et sévères. L'invention concerne également une méthode de traitement d'un sujet humain souffrant de dégénérescence articulaire, qui comprend l'exécution d’une ostéoplastie par abrasion sur une articulation affectée, suivie par l'administration locale à l'articulation affectée d'un nombre thérapeutiquement efficace de cellules souches mésenchymateuses humaines.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)