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1. (WO2017147196) METHODS FOR IDENTIFYING AND MODULATING IMMUNE PHENOTYPES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/147196 International Application No.: PCT/US2017/018963
Publication Date: 31.08.2017 International Filing Date: 22.02.2017
IPC:
C12Q 1/68 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants:
MASSACHUSETTS INSTITUTE OF TECHNOLOGY [US/US]; 77 Massachusetts Ave. Cambridge, MA 02139, US
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 1111 Franklin Street, 12th Floor Oakland, CA 94607, US
THE GENERAL HOSPITAL CORPORATION [US/US]; 55 Fruit Street Boston, MA 02114, US
SHALEK, Alexander, K. [US/US]; US
KOLB, Kellie, E. [US/US]; US
COLE, Michael, B. [US/US]; US
YOSEF, Nir [IL/US]; US
GAYO, Enrique, Martin [ES/US]; US
OUYANG, Zhengyu [CN/US]; US
YU, Xu [CN/US]; US
Inventors:
SHALEK, Alexander, K.; US
KOLB, Kellie, E.; US
COLE, Michael, B.; US
YOSEF, Nir; US
GAYO, Enrique, Martin; US
OUYANG, Zhengyu; US
YU, Xu; US
Agent:
KOWALSKI, Thomas, J.; US
VARSHNEYA, Pooja; US
KOWALSKI, Thomas, J.; US
RUSSEL, Mark, W.; US
CASSON, Lawrence, P.; US
Priority Data:
62/298,34922.02.2016US
Title (EN) METHODS FOR IDENTIFYING AND MODULATING IMMUNE PHENOTYPES
(FR) PROCÉDÉS D'IDENTIFICATION ET DE MODULATION DE PHÉNOTYPES IMMUNITAIRES
Abstract:
(EN) The present invention provides tools and methods for the systematic analysis of genetic interactions in immune cells. The present invention provides tools and methods for modulating immune cell phenotypes and compositions, combinatorial probing of cellular circuits, for dissecting cellular circuitry, for delineating molecular pathways, and/or for identifying relevant targets for therapeutics development.
(FR) La présente invention concerne des outils et des procédés d'analyse systématique des interactions génétiques dans des cellules immunitaires. Des outils et des procédés de modulation des phénotypes cellulaires immunitaires et des compositions, des procédés de sondage combinatoire de circuits cellulaires et de dissection de la machinerie cellulaire, des procédés de définition de voies moléculaires et/ou d'identification de cibles pertinentes pour le développement de produits thérapeutiques sont en outre décrits.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)