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1. (WO2017139885) METHOD AND SYSTEM FOR IMPROVING LATERAL RESOLUTION IN OPTICAL SCANNING MICROSCOPY
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/139885 International Application No.: PCT/CA2017/050195
Publication Date: 24.08.2017 International Filing Date: 15.02.2017
IPC:
G02B 21/00 (2006.01) ,G01N 33/483 (2006.01) ,G02B 21/06 (2006.01)
G PHYSICS
02
OPTICS
B
OPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
21
Microscopes
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
483
Physical analysis of biological material
G PHYSICS
02
OPTICS
B
OPTICAL ELEMENTS, SYSTEMS, OR APPARATUS
21
Microscopes
06
Means for illuminating specimen
Applicants:
UNIVERSITÉ LAVAL [CA/CA]; 2325, rue de l'Université Québec, Québec G1V 0A6, CA
Inventors:
THIBON, Louis; CA
DE KONINCK, Yves; CA
PICHÉ, Michel; CA
Agent:
ROBIC LLP; 1001 Square-Victoria, Bloc E - 8th Floor Montréal, Québec H2Z 2B7, CA
Priority Data:
62/295,81916.02.2016US
Title (EN) METHOD AND SYSTEM FOR IMPROVING LATERAL RESOLUTION IN OPTICAL SCANNING MICROSCOPY
(FR) PROCÉDÉ ET SYSTÈME D'AMÉLIORATION DE RÉSOLUTION LATÉRALE DE MICROSCOPIE À BALAYAGE OPTIQUE
Abstract:
(EN) A method and system for improving lateral resolution in optical microscopy are provided. The method includes generating a source optical beam and passing the source optical beam successively through an axicon, a Fourier-transform lens and an objective to convert the source optical beam into an excitation Bessel-type beam having a central lobe and at least one side lobe. The method also includes focusing the excitation beam onto a focal plane of the objective within or on a sample to generate a sample light signal, and spatially filtering the sample light signal. The spatial filtering includes rejecting light originating from outside of the focal plane and light generated by the at least one side lobe of the excitation beam. The spatial filtering also includes permitting passage, as a filtered light signal, of light generated by the central lobe of the excitation beam. The method further includes detecting the filtered light signal.
(FR) L'invention concerne un procédé et un système d'amélioration de résolution latérale de microscopie optique. Le procédé consiste à générer un faisceau optique source et à faire passer le faisceau optique source successivement à travers un axicon, une lentille à transformée de Fourier et un objectif pour convertir le faisceau optique source en un faisceau d'excitation de type Bessel possédant un lobe central et au moins un lobe latéral. Le procédé consiste également à focaliser le faisceau d'excitation sur un plan focal de l'objectif à l'intérieur d'un échantillon, ou sur ce dernier, afin de générer un signal lumineux d'échantillon, et à filtrer spatialement le signal lumineux d'échantillon. Le filtrage spatial consiste à rejeter de la lumière provenant de l'extérieur du plan focal et de la lumière générée par ledit lobe latéral du faisceau d'excitation. Le filtrage spatial consiste également à laisser passer, en tant que signal lumineux filtré, de la lumière générée par le lobe central du faisceau d'excitation. Le procédé consiste aussi à détecter le signal lumineux filtré.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
CA3013946EP3417331