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1. (WO2017139756) METHODS OF ASCERTAINING CROSS-SUBJECT QUANTITATIVE RELATIONSHIPS BETWEEN RESPONSE INDICATORS AMONG MULTIPLE SUBJECTS IN A POPULATION USING MULTIPOTENT OR PLURIPOTENT STEM CELLS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/139756 International Application No.: PCT/US2017/017659
Publication Date: 17.08.2017 International Filing Date: 13.02.2017
IPC:
A01N 63/00 (2006.01) ,C12N 5/00 (2006.01) ,C12Q 1/02 (2006.01) ,G01N 33/50 (2006.01) ,G01N 33/567 (2006.01)
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
N
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
63
Biocides, pest repellants or attractants, or plant growth regulators containing micro-organisms, viruses, microbial fungi, animals, e.g. nematodes, or substances produced by, or obtained from micro-organisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
02
involving viable micro-organisms
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
566
using specific carrier or receptor proteins as ligand binding reagent
567
utilising isolate of tissue or organ as binding agent
Applicants:
COYNE IP HOLDINGS, LLC [US/US]; 3931 Glenhurst Drive Smyrna, Georgia 30080, US
Inventors:
COYNE, Kevin P.; US
COYNE, Shawn T.; US
Agent:
GRAHAM, Jamie L.; US
HUFF, Jason D.; US
WADE, Kathryn H.; US
Priority Data:
62/294,10111.02.2016US
Title (EN) METHODS OF ASCERTAINING CROSS-SUBJECT QUANTITATIVE RELATIONSHIPS BETWEEN RESPONSE INDICATORS AMONG MULTIPLE SUBJECTS IN A POPULATION USING MULTIPOTENT OR PLURIPOTENT STEM CELLS
(FR) PROCÉDÉS DE VÉRIFICATION DE RELATIONS QUANTITATIVES DE SUJET CROISÉ ENTRE DES INDICATEURS DE RÉPONSE PARMI DE MULTIPLES SUJETS DANS UNE POPULATION À L'AIDE DE CELLULES SOUCHES MULTIPOTENTES OU PLURIPOTENTES
Abstract:
(EN) Methods are described herein for ascertaining how biological responses of one type, or due to one stimulus, are statistically related to any of: (1) biological reactions of another type; or (2) biological reactions due to a different stimulus; or (3) any biological feature of the stimulus, across multiple test subjects of a population. Assays and other methods of measurement are conducted on stem cells, multipotent or pluripotent stem cells or cells differentiated therefrom, of multiple test subjects of a population. By comparing various endpoints from one or more assays for a single subject, an arithmetic relationship between measured endpoints is established. By comparing arithmetic relationships across all of subjects of a population, it can be ascertain whether such relationships are common across all subjects of the population, related through a pattern (such as linear or non-linear correlations), or idiosyncratic to each subject.
(FR) L'invention concerne des procédés pour vérifier la manière dont des réponses biologiques d'un type, ou en raison d'un stimulus, sont statistiquement associées à : (1) des réactions biologiques d'un autre type ; ou (2) des réactions biologiques dues à un stimulus différent ; ou (3) toute caractéristique biologique du stimulus, sur de multiples sujets de test d'une population. Des analyses et d'autres procédés de mesure sont réalisés sur des cellules souches, des cellules souches multipotentes ou pluripotentes ou des cellules différenciées de ces dernières, de multiples sujets de test d'une population. En comparant diverses fins d'une ou plusieurs analyses pour un sujet unique, une relation arithmétique entre des fins mesurées est établie. En comparant des relations arithmétiques entre tous les sujets d'une population, on peut vérifier si ces relations sont communes à tous les sujets de la population, associées par un motif (telles que des corrélations linéaires ou non-linéaires), ou idiosyncratiques à chaque sujet.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)