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1. (WO2017139746) POSH INHIBITOR COMPLEX BIOMOLECULES AND AMPHIPHILE MICELLES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/139746 International Application No.: PCT/US2017/017638
Publication Date: 17.08.2017 International Filing Date: 13.02.2017
IPC:
A61K 9/107 (2006.01) ,A61K 38/16 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
107
Emulsions
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
Applicants:
DANIELS, Mark [US/US]; US
ULERY, Bret [US/US]; US
PORCIANI, David [IT/US]; US
TAWIAH, Kwaku [GH/US]; US
SMITH, Josiah [US/US]; US
CARDWELL, Leah [US/US]; US
BURKE, Donald [US/US]; US
NEWCOMER, Erin [US/US]; US
Inventors:
DANIELS, Mark; US
ULERY, Bret; US
PORCIANI, David; US
TAWIAH, Kwaku; US
SMITH, Josiah; US
CARDWELL, Leah; US
BURKE, Donald; US
NEWCOMER, Erin; US
Agent:
SELLERS, Andrea, F.; US
Priority Data:
62/294,15411.02.2016US
Title (EN) POSH INHIBITOR COMPLEX BIOMOLECULES AND AMPHIPHILE MICELLES
(FR) BIOMOLÉCULES COMPLEXES ET MICELLES AMPHIPHILES INHIBITRICES DE POSH
Abstract:
(EN) The present invention is directed to a composition that includes an amphiphile, its use in a method of preventing and/or treating cancer, and its use in a method of producing a pharmaceutical composition. In certain embodiments, the amphiphile includes a hydrophilic peptide that binds to a Plenty of SH3 domain (POSH) and inhibits or disrupts a POSH scaffold network, a hydrophobic moiety, and an aptamer. The present invention is also directed to other POSH inhibitor complex biomolecules that do not contain a hydrophobic moiety.
(FR) La présente invention concerne une composition contenant un amphiphile, son utilisation dans une méthode de prévention et/ou de traitement du cancer, et son utilisation dans un procédé de production d'une composition pharmaceutique. Dans certains modes de réalisation, l'amphiphile comprend un peptide hydrophile qui se lie à un domaine Pleine de SH3 (POSH) et inhibe ou interrompt un réseau de protéines d'échafaudage POSH, ainsi qu'une partie hydrophobe et un aptamère. La présente invention concerne également d'autres biomolécules complexes inhibitrices de POSH ne contenant pas de partie hydrophobe.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
US20190040390