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1. (WO2017139736) MEASUREMENT OF ALS PROGRESSION BASED ON KINETIC DATA
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/139736 International Application No.: PCT/US2017/017610
Publication Date: 17.08.2017 International Filing Date: 13.02.2017
IPC:
A61B 5/11 (2006.01) ,A61B 5/00 (2006.01) ,A61B 5/053 (2006.01) ,A61B 5/103 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
B
DIAGNOSIS; SURGERY; IDENTIFICATION
5
Measuring for diagnostic purposes; Identification of persons
103
Measuring devices for testing the shape, pattern, size or movement of the body or parts thereof, for diagnostic purposes
11
Measuring movement of the entire body or parts thereof, e.g. head or hand tremor or mobility of a limb
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
B
DIAGNOSIS; SURGERY; IDENTIFICATION
5
Measuring for diagnostic purposes; Identification of persons
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
B
DIAGNOSIS; SURGERY; IDENTIFICATION
5
Measuring for diagnostic purposes; Identification of persons
05
Measuring for diagnosis by means of electric currents or magnetic fields
053
Measuring electrical impedance or conductance of a portion of the body
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
B
DIAGNOSIS; SURGERY; IDENTIFICATION
5
Measuring for diagnostic purposes; Identification of persons
103
Measuring devices for testing the shape, pattern, size or movement of the body or parts thereof, for diagnostic purposes
Applicants:
ALS THERAPY DEVELOPMENT INSTITUTE [US/US]; 300 Technology Square, Suite 400 Cambridge, Massachusetts 02139, US
Inventors:
GILL, Alan; US
PERRIN, Steven; US
AL-NAKHALA, Bashar; US
Agent:
ENGELLENNER, Thomas, J.; US
Priority Data:
62/294,63312.02.2016US
Title (EN) MEASUREMENT OF ALS PROGRESSION BASED ON KINETIC DATA
(FR) MESURE DE PROGRESSION DE LA SCLÉROSE LATÉRALE AMYOTROPHIQUE (ALS) SUR LA BASE DE DONNÉES CINÉTIQUES
Abstract:
(EN) Methods and systems are disclosed for evaluating a neurological condition by employing at least one motion sensor, configured to be attached to a body appendage, a memory associated with the sensor(s) to periodically record movement data during periods of prescribed exercises; and a processor for analyzing changes in movement data over time to evaluate the progression of the neurological condition. In one embodiment, the neurological condition is ALS and at least four motion sensors are employed such that each arm and leg of the patient has an associated sensor. The sensors can be accelerometers that measure the displacement, velocity and acceleration of an associated limb during periods of prescribed exercise. For example, changes in the patients ability to repeat a series of limb-lifting exercises or the measurement of limb tremors associated with the conduct of the exercises can be correlated with norms and analyzed to classify the stage of ALS in a patient and/or predict the rate of progression.
(FR) L'invention concerne des procédés et systèmes permettant d'évaluer un état neurologique en utilisant au moins un capteur de mouvements conçu pour être fixé sur un appendice corporel, une mémoire associée au(x) capteur(s) pour l'enregistrement périodique de données de mouvements pendant des périodes d'exercices prescrits ; et un processeur destiné à analyser des changements dans des données de mouvements dans le temps afin d'évaluer la progression de l'état neurologique. Dans un mode de réalisation, l'état neurologique est une sclérose latérale amyotrophique (ALS) et au moins quatre capteurs de mouvements sont utilisés de telle sorte que chaque bras et chaque jambe du patient comprennent un capteur associé. Les capteurs peuvent être des accéléromètres qui mesurent le déplacement, la vitesse et l'accélération d'un membre associé pendant des périodes d'exercices prescrits. Par exemple, des changements dans la capacité de patients à répéter une série d'exercices de levée de membres ou la mesure de tremblements associés à l'exécution de ces exercices peuvent être corrélés à des normes et analysés pour la classification du stade de l'ALS chez un patient et/ou la prédiction de la vitesse de progression de l'ALS.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU2017218129KR1020180111872CN108778121EP3413796CA3014340