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1. (WO2017139417) COMPOSITIONS WITH IMPROVED INTRAVITREAL HALF-LIFE AND USES THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/139417 International Application No.: PCT/US2017/017066
Publication Date: 17.08.2017 International Filing Date: 08.02.2017
IPC:
C12N 15/115 (2010.01) ,A61K 31/7088 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
115
Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
Applicants:
VITRISA THERAPEUTICS, INC. [US/US]; 700 Larkspur Landing Circle Larkspur, CA 94939, US
Inventors:
ERICKSON, Carl; US
RUSCONI, Christopher, P.; US
MCLURE, Kevin, G.; US
HUTABARAT, Renta; US
Agent:
BARKER, Adrian; US
ALEMOZAFAR, Ali; US
ALMEDA, Dariela; US
BARKER, Adrian; US
ADVANI, Raj; US
Priority Data:
62/292,81708.02.2016US
Title (EN) COMPOSITIONS WITH IMPROVED INTRAVITREAL HALF-LIFE AND USES THEREOF
(FR) COMPOSITIONS À DEMI-VIE INTRAVITRÉENNE AMÉLIORÉE ET LEURS UTILISATIONS
Abstract:
(EN) Provided herein are compositions and methods for the treatment of retinal diseases. The compositions and methods include a therapeutic agent conjugated to a vitreous component binding moiety. The vitreous component binding moiety may be an aptamer or a small molecule that binds to a structural component of the vitreous humor (e.g., hyaluronic acid, collagen or vitronectin).
(FR) La présente invention concerne des compositions et des méthodes de traitement de maladies rétiniennes. Les compositions et les méthodes font appel à un agent thérapeutique conjugué à une fraction de liaison de composant vitreux. La fraction de liaison de composant vitreux peut être un aptamère ou une petite molécule qui se lie à un composant structural de l'humeur vitrée (par exemple, l'acide hyaluronique, le collagène ou la vitronectine).
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU2017217677CA3012718EP3414330CN109072241