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1. (WO2017139415) SCAVENGER COMPOUNDS FOR IMPROVED SEQUENCING-BY-SYNTHESIS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/139415 International Application No.: PCT/US2017/017064
Publication Date: 17.08.2017 International Filing Date: 08.02.2017
IPC:
C12Q 1/06 (2006.01) ,A61K 31/404 (2006.01) ,G01N 33/52 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
02
involving viable micro-organisms
04
Determining presence or kind of micro-organism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
06
Quantitative determination
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
403
condensed with carbocyclic rings, e.g. carbazole
404
Indoles, e.g. pindolol
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
52
Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper
Applicants:
QIAGEN WALTHAM, INC. [US/US]; 35 Gatehouse Drive Waltham, MA 02451-1215, US
Inventors:
ANDRUZZI, Luisa; US
Agent:
CARROLL, Peter, G.; Medlen & Carroll, LLP 1440 Broadway, Suite 510 Oakland, CA 94612, US
Priority Data:
62/293,96911.02.2016US
Title (EN) SCAVENGER COMPOUNDS FOR IMPROVED SEQUENCING-BY-SYNTHESIS
(FR) COMPOSÉS PIÉGEURS POUR UN SÉQUENÇAGE PAR SYNTHÈSE AMÉLIORÉ
Abstract:
(EN) The present invention discloses methods of applications of indole-3-propionic acid, L-carnitine and O-acetyl-L-camitine in one or more different reactive steps of a sequencing-by-synthesis workflow. The reactive steps employing these compounds include, but are not limited to, cleaving, imaging, incorporating bases and washing. The use of these new compounds provides improved sequencing performance including, but not limited to, lower error rates, higher sequence outputs and/or longer read lengths.
(FR) La présente invention concerne des procédés d'applications de l'acide indole-3-propionique, de la L-carnitine et O-acétyl-L-carnitine dans une ou plusieurs étapes réactives différentes d'un processus de séquençage par synthèse. Les étapes réactives utilisant ces composés comprennent, entre autres, le clivage, l'imagerie, l'incorporation de bases et le lavage. L'utilisation de ces nouveaux composés permet d'obtenir des performances de séquençage améliorées comprenant, entre autres, des taux d'erreur plus bas, des générations de séquences supérieures et/ou des longueurs de lectures plus longues.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)