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1. (WO2017138810) PREDICTING RESPONSE TO IMMUNOMODULATORY DRUGS (IMIDS) IN MULTIPLE MYELOMA PATIENTS
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Pub. No.: WO/2017/138810 International Application No.: PCT/NL2017/050077
Publication Date: 17.08.2017 International Filing Date: 09.02.2017
IPC:
G01N 33/574 (2006.01) ,C12Q 1/68 (2006.01) ,A61K 31/445 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
574
for cancer
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
445
Non-condensed piperidines, e.g. piperocaine
Applicants:
SKYLINEDX B.V. [NL/NL]; Marconistraat 16 3029 AK Rotterdam, NL
ERASMUS UNIVERSITY MEDICAL CENTER ROTTERDAM [NL/NL]; Dr. Molewaterplein 50 3015 GE Rotterdam, NL
Inventors:
SONNEVELD, Pieter; NL
VAN VLIET, Martinus Hendrikus; NL
DE BEST, Cornelia Maria; NL
Agent:
JANSEN, C.M.; NL
Priority Data:
16155477.912.02.2016EP
Title (EN) PREDICTING RESPONSE TO IMMUNOMODULATORY DRUGS (IMIDS) IN MULTIPLE MYELOMA PATIENTS
(FR) PRÉDICTION DE LA RÉPONSE À DES MÉDICAMENTS IMMUNOMODULATEURS (IMID) CHEZ DES PATIENTS ATTEINTS DE MYÉLOME MULTIPLE
Abstract:
(EN) The present disclosure relates to methods and kits for classifying an individual afflicted with multiple myeloma based on the likelihood of response to immunomodulatory drugs (IMiDs), such as thalidomide and lenalidomide. The disclosure further relates to methods of treating an individual afflicted with multiple myeloma with an IMiD and with methods for determining a therapy regime based on the likelihood of response to an IMiD as a result of genetic characteristic of the patient.
(FR) La présente divulgation concerne des méthodes et des kits permettant de classer un sujet atteint de myélome multiple sur la base de sa probabilité de réponse à des médicaments immunomodulateurs (IMID), tels que le thalidomide et le lénalidomide. Des méthodes destinées à traiter un sujet atteint de myélome multiple à l'aide d'un IMID et de méthodes permettant de déterminer un schéma thérapeutique basé sur la probabilité de réponse à un IMID résultant d'une caractéristique génétique du patient sont en outre décrites.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)