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1. (WO2017138696) DETECTION METHOD AND ELECTROCHEMICAL DETECTION KIT FOR AGGREGATE FORM OF PROTEIN, AND DIAGNOSTIC METHOD AND ELECTROCHEMICAL DIAGNOSTIC KIT FOR DISEASES ASSOCIATED WITH ABNORMAL PROTEIN AGGREGATION BY USING SAME
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/138696 International Application No.: PCT/KR2016/015393
Publication Date: 17.08.2017 International Filing Date: 28.12.2016
IPC:
G01N 27/02 (2006.01) ,G01N 33/68 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
27
Investigating or analysing materials by the use of electric, electro-chemical, or magnetic means
02
by investigating impedance
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68
involving proteins, peptides or amino acids
Applicants:
주식회사 캔티스 CANTIS [KR/KR]; 경기도 안산시 상록구 해안로 705, 경기테크노파크알아이티센터 610호 (사동) (Sa-dong) Gyeonggi Techno Park RIT center #610, 705, Haean-ro, Sangnok-gu, Ansan-si, Gyeonggi-do 15588, KR
Inventors:
조원우 CHO, Won Woo; KR
고경옥 KO, Kyung Ok; KR
박종배 PARK, Jong Bae; KR
르반롱 LE VAN, Long; KR
이준옥 LEE, Jun Ok; KR
Agent:
두호특허법인 DOOHO IP LAW FIRM; 서울시 서초구 강남대로 51길 1, 7층 (서초동, 대현블루타워) (Seocho-dong, Daehyun Blue Tower) 7th Floor, 1, Gangnam-daero 51-gil, Seocho-gu, Seoul 06628, KR
Priority Data:
10-2016-001643412.02.2016KR
10-2016-016200230.11.2016KR
Title (EN) DETECTION METHOD AND ELECTROCHEMICAL DETECTION KIT FOR AGGREGATE FORM OF PROTEIN, AND DIAGNOSTIC METHOD AND ELECTROCHEMICAL DIAGNOSTIC KIT FOR DISEASES ASSOCIATED WITH ABNORMAL PROTEIN AGGREGATION BY USING SAME
(FR) MÉTHODE DE DÉTECTION ET KIT DE DÉTECTION ÉLECTROCHIMIQUE POUR UNE FORME AGRÉGÉE DE PROTÉINE ET MÉTHODE DE DIAGNOSTIC ET KIT DE DIAGNOSTIC ÉLECTROCHIMIQUE POUR DES MALADIES ASSOCIÉES À UNE AGRÉGATION ANORMALE DE PROTÉINES À L'AIDE DE CEUX-CI
(KO) 단백질 응집형의 검출 방법, 전기화학적 검출 키트 및 이를 이용한 비정상 단백질 응집 관련 질병의 진단 방법 및 전기화학적 진단 키트
Abstract:
(EN) The present invention relates to a method and a kit for detecting an aggregate form of a protein, comprising the steps of: adding a bio-sample containing protein aggregates to a plurality of antibodies for the protein so as to measure a first impedance; monomerizing the protein aggregates so as to measure a second impedance; and comparing the first impedance with the second impedance, thereby quantitatively analyzing, by a simple method in real time, how many proteins are present in the bio-sample in an aggregate form, so as to be widely usable in the diagnosis of diseases associated with abnormal protein aggregation.
(FR) La présente invention concerne une méthode et un kit de détection d'une forme agrégée d'une protéine, comprenant les étapes consistant à : ajouter un échantillon biologique contenant des agrégats de protéines à une pluralité d'anticorps pour la protéine de sorte à mesurer une première impédance ; monomériser les agrégats de protéine de sorte à mesurer une seconde impédance ; et comparer la première impédance à la seconde impédance, ce qui permet d'analyser de manière quantitative, par une méthode simple en temps réel, le nombre de protéines qui sont présentes dans l'échantillon biologique sous une forme agrégée, de sorte à être largement utilisable dans le diagnostic de maladies associées à une agrégation anormale de protéines.
(KO) 본 발명은 단백질 응집체를 포함하는 생시료를 상기 단백질의 복수개의 항체에 가하여 제1 임피던스를 측정하는 단계; 상기 단백질 응집체를 단량체화하여 제2 임피던스를 측정하는 단계; 및 상기 제1 및 제2 임피던스를 비교하는 단계;를 포함함으로써, 단백질이 생시료 내에서 얼마나 많이 응집형으로 존재하는지 여부를 간단한 방법으로 정량적으로 실시간 분석하여, 비정상 단백질 응집과 관련된 질병의 진단에 폭넓게 활용될 수 있는 단백질 응집형의 검출 방법 및 검출 키트에 관한 것이다.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Korean (KO)
Filing Language: Korean (KO)