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1. (WO2017137920) USE OF BACTERIAL STRAINS BELONGING TO THE SPECIES LACTOBACILLUS KEFIRI IN PAEDIATRICS TO GENERATE AND/OR MAINTAIN A STATE OF HOMEOSTASIS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/137920 International Application No.: PCT/IB2017/050713
Publication Date: 17.08.2017 International Filing Date: 09.02.2017
IPC:
C12N 1/20 (2006.01) ,A61K 35/747 (2015.01) ,A23L 33/135 (2016.01) ,C12R 1/225 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
1
Micro-organisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving micro-organisms or compositions thereof; Processes of preparing or isolating a composition containing a micro-organism; Culture media therefor
20
Bacteria; Culture media therefor
[IPC code unknown for A61K 35/747][IPC code unknown for A23L 33/135]
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
R
INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C-C12Q75
1
Micro-organisms
01
Bacteria or actinomycetales
225
Lactobacillus
Applicants:
PROBIOTICAL S.P.A. [IT/IT]; Via E. Mattei, 3 28100 Novara NO, IT
HULKA S.R.L. [IT/IT]; Viale della Scienza 26 45100 Rovigo, IT
Inventors:
MOGNA, Giovanni; IT
Agent:
HOFFMANN EITLE S.R.L.; Piazza Sigmund Freud 1 Torre 2, Piano 22 20154 Milano, IT
ZANGS, Rainer E.; IT
KINDLER, Matthias; IT
FRANK, Veit Peter; IT
POLZ, Leo; IT
STEIN-DRÄGER, Christiane; IT
AVERY, Stephen John; IT
LETHEM, David James; IT
MARSH, Roy David; IT
MITCHELL, Alan; IT
FURLONG, Christopher Heinrich; IT
BAUSCH, Thorsten; IT
TAORMINO, Joseph Paul; IT
KLUSMANN, Peter; IT
SCHWEIGHART, Peter; IT
WOLF, Matthias; IT
SIEGERT, Georg; IT
MAYRHOFER, Stefan; IT
STRATMANN, Klemens; IT
WIEDEMANN, Peter; IT
VON KUROWSKI, Lorenz; IT
BECHER, Claus Thomas; IT
SPILGIES, Jan-Hendrik; IT
RENKEN, Joachim; IT
ENGELHARD, Elisabeth; IT
BACHELIN, Karl Martin Raimund; IT
DISSER, Stephan; IT
VAN BOUWELEN, Franciscus Maria; IT
FÜCHSLE, Kathrin; IT
CIESLA, Ulrike; IT
SCHÖN, Anne Katrin; IT
VOCKE, Henrik; IT
GÖRG, Andreas; IT
GARBERG, Morten; IT
RUSSELL, John Alistair; IT
SPROSTON, David; IT
THIRLWELL, Karen; IT
SCHEIBLE, Dominik; IT
VOS, Bianca-Lucia; IT
DOUXCHAMPS, Nicolas; IT
STEFFERL, Andreas; IT
GOLLER, Daniel; IT
PRUSS, Timo; IT
WERNER-JONES, Leonard L.; IT
BACCELLI, Michele; IT
MÜLLER, Markus Georg; IT
MUNCKE, Nadja; IT
CORNEO, Giovanni; IT
STREGE, Christine; IT
DRAGOSAVAC, Marko; IT
BIRKETT, Matthew; IT
ZILLIES, Jan Carl; IT
GROHS, Daniel; IT
MULHERN, Declan; IT
GRIMM, Stephan; IT
TILLMANN, Volker; IT
OGLE, James Matthew; IT
GLAS, Johannes Dominik; IT
STEINMÜLLER, Stephan; IT
BENEDETTO, Marco; IT
LEVINE, Benjamin; IT
JONES, Mark A. G.; IT
GRAEBER, Jens; IT
FUSTER, Gustavo; IT
ESSER, Axel T.; IT
SCHIEREN, Roland; IT
RECKENTHÄLER, Peter; IT
CATANIA, Olivier; IT
DÖRFEL, Katrin; IT
WEINMANN, Lasse; IT
SASSE, Stefan; IT
Priority Data:
10201600001490712.02.2016IT
10201600004805810.05.2016IT
Title (EN) USE OF BACTERIAL STRAINS BELONGING TO THE SPECIES LACTOBACILLUS KEFIRI IN PAEDIATRICS TO GENERATE AND/OR MAINTAIN A STATE OF HOMEOSTASIS
(FR) UTILISATION DE SOUCHES BACTÉRIENNES APPARTENANT À L'ESPÈCE LACTOBACILLUS KEFIRI EN PÉDIATRIE POUR GÉNÉRER ET/OU MAINTENIR UN ÉTAT D'HOMÉOSTASIE
Abstract:
(EN) The present invention relates to the use of bacterial strains belonging to the species Lactobacillus kefiri in paediatrics to generate and/or maintain the state of homeostasis. The present invention further relates to bacterial strains belonging to the species Lactobacillus kefiri having a high capacity to adhere to the intestinal epithelium; in particular, the present invention relates to the bacterial strains Lactobacillus kefiri LKF01 DSM 32079 LKEF and Lactobacillus kefiri LKF02 DSM 32080 for use in paediatrics. Finally, the present invention relates to a food composition, or a composition for a supplement, or a composition for a medical device, or a pharmaceutical composition (briefly all together the composition(s) of the present invention) comprising excipients and/or substances of a food or pharmaceutical grade formulation, and a mixture which comprises or, alternatively, consists of a bacterial strain selected from the group consisting of the bacterial strains belonging to the species Lactobacillus kefiri, said composition being for use in paediatrics to generate and/or maintain the state of homeostasis and for use in the preventive and/or curative treatment of inflammatory intestinal diseases, such as irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), Crohn's disease and ulcerative colitis (UC), in adult subjects, also in a chronic stage.
(FR) La présente invention concerne l'utilisation de souches bactériennes appartenant à l'espèce Lactobacillus kefiri en pédiatrie pour générer et/ou maintenir l'état d'homéostasie. La présente invention concerne en outre des souches bactériennes appartenant à l'espèce Lactobacillus kefiri ayant une capacité élevée à adhérer à l'épithélium intestinal ; en particulier, la présente invention concerne les souches bactériennes Lactobacillus kefiri LKF01 DSM 32079 LKEF et Lactobacillus kefiri LKF02 DSM 32080 pour une utilisation en pédiatrie. Enfin, la présente invention concerne une composition alimentaire, ou une composition pour un supplément, ou une composition pour un dispositif médical, ou une composition pharmaceutique (brièvement toutes ensemble la composition (les compositions) de la présente invention) comprenant des excipients et/ou des substances d'une formulation de qualité alimentaire ou pharmaceutique, et un mélange qui comprend ou, en variante, consiste en une souche bactérienne sélectionnée dans le groupe constitué des souches bactériennes appartenant à l'espèce Lactobacillus kefiri, ladite composition étant destinée à être utilisée en pédiatrie pour générer et/ou maintenir l'état d'homéostasie et pour une utilisation dans le traitement préventif et/ou curatif de maladies intestinales inflammatoires, telles que le syndrome du côlon irritable (IBS)), une affection abdominale inflammatoire (IBD), la maladie de Crohn et la rectocolite hémorragique (UC), chez des sujets adultes, également à un stade chronique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: Italian (IT)
Also published as:
AU2017217350CA3013280CN108779433EP3414317BR112018016458US20190038682