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1. (WO2017137910) PROCESSES FOR THE PREPARATION OF HIGHLY PURE PRUCALOPRIDE SUCCINATE AND ITS INTERMEDIATES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/137910 International Application No.: PCT/IB2017/050696
Publication Date: 17.08.2017 International Filing Date: 09.02.2017
IPC:
A61K 31/4525 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
435
having six-membered rings with one nitrogen as the only ring hetero atom
44
Non-condensed pyridines; Hydrogenated derivatives thereof
445
Non-condensed piperidines, e.g. piperocaine
4523
containing further heterocyclic ring systems
4525
containing a five-membered ring with oxygen as a ring hetero atom
Applicants:
SYMED LABS LIMITED [IN/IN]; 8-2-293/174/3, Beside BN Reddy Colony, Road No. 14, Banjara Hills, Hyderabad, Telangana 500 034, IN
Inventors:
MOHAN RAO, Dodda; IN
VENUGOPAL, Bingi; IN
Priority Data:
20164100481511.02.2016IN
Title (EN) PROCESSES FOR THE PREPARATION OF HIGHLY PURE PRUCALOPRIDE SUCCINATE AND ITS INTERMEDIATES
(FR) PROCÉDÉS POUR LA PRÉPARATION DE SUCCINATE DE PRUCALOPRIDE TRÈS PUR ET DE SES INTERMÉDIAIRES
Abstract:
(EN) Provided herein are purification processes for the preparation of highly pure prucalopride succinate salt. Provided also herein are improved, commercially viable and industrially advantageous processes for the preparation of Prucalopride and its intermediate compounds, for example, methyl 4-acetylamino-5-chloro-2,3-dihydrobenzo[b]furan-7-carboxylate and alkyl 4-[[(4-amino-5-chloro-2,3-dihydro-7-benzofuranyl)carbonyl]-amino]-1-piperidinecarboxylate.
(FR) L'invention concerne des procédés de purification pour la préparation de sel de succinate de prucalopride très pur. L'invention concerne également des procédés améliorés, commercialement viables et industriellement avantageux pour la préparation de prucalopride et de ses composés intermédiaires, par exemple le méthyl 4-acétylamino-5-chloro -2,3-dihydrobenzo[b]furan-7-carboxylate et l'alkylcarboxylate de 4-[[(4-amino-5-chloro -2,3-dihydro-7-benzofuranyl)carbonyl]amino]-1-piperidine.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP3413891