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1. (WO2017137727) TB BIOMARKERS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/137727 International Application No.: PCT/GB2017/050272
Publication Date: 17.08.2017 International Filing Date: 03.02.2017
IPC:
G01N 33/569 (2006.01) ,A61K 38/00 (2006.01) ,C12Q 1/68 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
569
for micro-organisms, e.g. protozoa, bacteria, viruses
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants:
MEDICAL RESEARCH COUNCIL [GB/GB]; 2nd Floor, David Philips Building, Polaris House North Star Avenue Swindon SN2 1FL, GB
IMPERIAL INNOVATIONS LIMITED [GB/GB]; 52 Princes Gate South Kensington London SW7 2AZ, GB
Inventors:
KAMPMANN, Beate; GB
TOGUN, Toyin; CA
HOGGART, Clive Julian; GB
Agent:
SCRIPT IP LIMITED; Turnpike House 18 Bridge Street Frome, Somerset BA11 1BB, GB
RICHARDS, William; GB
Priority Data:
1602305.309.02.2016GB
Title (EN) TB BIOMARKERS
(FR) BIOMARQUEURS DE TB
Abstract:
(EN) The invention relates to a method for the diagnosis of TB in a subject, the method comprising (a) providing a sample from said subject, said sample being selected from the group consisting of: blood, serum and plasma; (b) determining the concentration in said sample of the following biomarkers: IL-1ra, IL6, IL-7, IL-8, IL-12p70, FGF-basic, IP- 10, and VEGF; (c) converting each biomarker concentration determined in (b) into a decile value; and (d) converting each decile value into a binary presence or absence by comparing the decile values of (c) to the following specific quantile cut off values wherein a decile value matching or exceeding the specific quantile cut-off value is converted into the binary presence of the biomarker, and a decile value lower than the specific quantile cut-off value is converted into the binary absence of the biomarker; wherein detecting the presence of each of said biomarkers indicates that the subject has TB. The invention also relates to uses, kits and devices.
(FR) L'invention concerne un procédé de diagnostic de la tuberculose (TB) chez un sujet, le procédé consistant à (a) fournir un échantillon provenant dudit sujet, ledit échantillon étant choisi dans le groupe constitué par le sang, le sérum et le plasma ; (b) déterminer la concentration dans ledit échantillon des biomarqueurs suivants : IL-1ra, IL6, IL-7, IL-8, IL-12p70, FGF basique, IP-10, et VEGF ; (c) convertir chaque concentration de biomarqueur déterminée en (b) en une valeur de décile ; et (d) convertir chaque valeur de décile en une présence ou absence binaire par comparaison des valeurs de décile de (c) avec les valeurs de coupure de quantile spécifiques suivantes, une valeur de décile correspondant ou dépassant la valeur de coupure de quantile spécifique étant convertie en la présence binaire du biomarqueur, et une valeur de décile inférieure à la valeur de coupure de quantile spécifique étant convertie en l'absence binaire du biomarqueur ; la détection de la présence de chacun desdits biomarqueurs indiquant que le sujet a la tuberculose. L'invention concerne également des utilisations, des kits et des dispositifs.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU2017218546CA3013119CN108779493IN201817033097EP3414572US20190062812
BR112018016171