PATENTSCOPE will be unavailable a few hours for maintenance reason on Tuesday 19.11.2019 at 4:00 PM CET
Search International and National Patent Collections
Some content of this application is unavailable at the moment.
If this situation persists, please contact us atFeedback&Contact
1. (WO2017137458) ANTIBODY-CONJUGATES WITH IMPROVED THERAPEUTIC INDEX FOR TARGETING CD30 TUMOURS AND METHOD FOR IMPROVING THERAPEUTIC INDEX OF ANTIBODY-CONJUGATES



Disclaimer The image version (PDF) available on PATENTSCOPE is the official version. This online html version is provided to assist users. Despite the great care taken in its compilation to ensure a precise and accurate representation of the data appearing on the printed document/images, errors and/or omissions cannot be excluded due to the data transmittal, conversion and inherent limitations of the (optional) machine translation processes used. Hyperlinks followed by this symbol , are to external resources that are not controlled by WIPO. WIPO disclaims all liability regarding the above points.

INTERNATIONAL SEARCH REPORT (ISR)
Part 1:  1  2  3  4  5  6          Part 2:  A  B  C  D  E 
International application No. Applicant's or agent's file reference
PCT/EP2017/052791 P6061998PCT
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
08 February 2017 08 February 2016
Applicant
SYNAFFIX B.V.
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
b.
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
c.
1. With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
a. forming part of the international application as filed:
in the form of an Annex C/ST.25 text file.
on paper or in the form of an image file.
b. furnished together with the international application under PCT Rule 13ter.1(a) for the purposes of international search only in the form of an Annex C/ST.25 text file.
c. furnished subsequent to the international filing date for the purposes of international search only:
in the form of an Annex C/ST.25 text file (Rule 13ter.1(a)).
on paper or in the form of an image file (Rule 13ter.1(b) and Administrative Instructions, Section 713).
2.
In addition, in the case that more than one version or copy of a sequence listing has been filed or furnished, the required statements that the information in the subsequent or additional copies is identical to that forming part of the application as filed or does not go beyond the application as filed, as appropriate, were furnished.
3.
Additional comments:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
ANTIBODY-CONJUGATES WITH IMPROVED THERAPEUTIC INDEX FOR TARGETING CD30 TUMOURS AND METHOD FOR IMPROVING THERAPEUTIC INDEX OF ANTIBODY-CONJUGATES

5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
a.
The figure of the drawings to be published with the abstract is Figure No. ____________
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
b.
none of the figures is to be published with the abstract.

A. CLASSIFICATION OF SUBJECT MATTER

     A61K 47/34 (2017.01)i; A61K 47/42 (2017.01)i; A61K 47/59 (2017.01)i; A61K 47/68 (2017.01)i; A61P 35/00 (2006.01)i; A61P 35/02 (2006.01)i
According to International Patent Classification (IPC) or to both national classification and IPC

B. FIELDS SEARCHED

Minimum documentation searched (classification system followed by classification symbols):
     A61K; A61P
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
EPO-Internal, EMBASE, BIOSIS, WPI Data

C. DOCUMENTS CONSIDERED TO BE RELEVANT

Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
(1)
X
WO 2014065661 A1 (SYNAFFIX BV [NL]) 01 May 2014 (2014-05-01)
1,2,6-11,13-16,18
the whole document
pages 7-17
page 19
pages 32-71
examples 17-37
(2)
X
WO 2015057066 A1 (SYNAFFIX BV [NL]) 23 April 2015 (2015-04-23)
1,2,4,6-11,13-16,18
the whole document
page 7, line 21 - page 8, line 32
page 18, line 8 - page 19, line 4
scheme 1;page 21
page 34, line 5 - page 38, line 2
page 74, line 30 - page 76, line 2
page 79 - page 80; claims 1-15; examples 4,8-15
(3)
X
WO 2015057065 A1 (SYNAFFIX BV [NL]) 23 April 2015 (2015-04-23)
1,2,4,6-11,13-16,18
the whole document
examples 1-13
(4)
X
WO 2015057063 A1 (SYNAFFIX BV [NL]) 23 April 2015 (2015-04-23)
1,2,4,6-11,13-16,18
the whole document
examples 9-22,33,34
(5)
X,P
WO 2016053107 A1 (SYNAFFIX BV [NL]) 07 April 2016 (2016-04-07)
1-3,6-11,13-16,18
cited in the application
the whole document
page 81, line 3 - page 83, line 19; claims 1-19; figures 3-7; examples 15,16
(6)
X,P
WO 2016170186 A1 (SYNAFFIX BV [NL]) 27 October 2016 (2016-10-27)
1,2,6-11,13-16,18
cited in the application
the whole document
pages 01-105; examples 1-26
(7)
A
WO 2015057064 A1 (SYNAFFIX BV [NL]) 23 April 2015 (2015-04-23)
1-18
the whole document
(8)
A
WO 2014177771 A1 (GLYKOS FINLAND OY [FI]) 06 November 2014 (2014-11-06)
1-18
the whole document
(9)
A
JEFFREY SCOTT C ET AL, "Development and properties of beta-glucuronide linkers for monoclonal antibody-drug conjugates", BIOCONJUGATE CHEMISTRY,,Vol. 17, No. 3, 01 May 2006 (2006-05-01), page 831-840,
XP002423719
1-18
the whole document
(10)
A
F. LHOSPICE ET AL, "Site-Specific Conjugation of Monomethyl Auristatin E to Anti-CD30 Antibodies Improves Their Pharmacokinetics and Therapeutic Index in Rodent Models", MOLECULAR PHARMACEUTICS,Vol. 12, No. 6, 01 June 2015 (2015-06-01), page 1863-1871,
XP055327463
1-18
the whole document
(11)
A
BEERLI R R ET AL, "Sortase Enzyme-Mediated Generation of Site-Specifically Conjugated Antibody Drug Conjugates with High In Vitro and In Vivo Potency", 01 July 2015 (2015-07-01), Vol. 10, No. 7, page e0131177-1,
XP002756397
[retrieved on  2015-01-01]
1-18
the whole document
*
Special categories of cited documents:
"A"
document defining the general state of the art which is not considered to be of particular relevance
"E"
earlier application or patent but published on or after the international filing date
"L"
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
"O"
document referring to an oral disclosure, use, exhibition or other means
"P"
document published prior to the international filing date but later than the priority date claimed
"T"
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
"X"
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
"Y"
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
"&"
document member of the same patent family

D. INFORMATION ON PATENT FAMILY MEMBERS

Patent document cited in search report Publication date
(day/month/year)
Patent family member(s) Publication date
(day/month/year)
WO 2014065661 A1
01 May 2014
CN 105142672 A
EP 2911699 A1
JP 2015534996 A
US 2015258210 A1
US 2015320882 A1
WO 2014065661 A1
09 December 2015
02 September 2015
07 December 2015
17 September 2015
12 November 2015
01 May 2014
WO 2015057066 A1
23 April 2015
CN 105829543 A
EP 2935611 A1
JP 2016538878 A
US 2016257764 A1
WO 2015057066 A1
03 August 2016
28 October 2015
15 December 2016
08 September 2016
23 April 2015
WO 2015057065 A1
23 April 2015
EP 3057618 A1
US 2016235861 A1
WO 2015057065 A1
24 August 2016
18 August 2016
23 April 2015
WO 2015057063 A1
23 April 2015
CN 105814213 A
EP 2935608 A1
JP 2016538877 A
US 2016280797 A1
WO 2015057063 A1
27 July 2016
28 October 2015
15 December 2016
29 September 2016
23 April 2015
WO 2016053107 A1
07 April 2016
EP 3134128 A1
US 2017072068 A1
WO 2016053107 A1
01 March 2017
16 March 2017
07 April 2016
WO 2016170186 A1
27 October 2016
EP 3134520 A1
US 2017130256 A1
WO 2016170186 A1
01 March 2017
11 May 2017
27 October 2016
WO 2015057064 A1
23 April 2015
EP 3058083 A1
US 2016250347 A1
WO 2015057064 A1
24 August 2016
01 September 2016
23 April 2015
WO 2014177771 A1
06 November 2014
EP 2991683 A1
US 2016106860 A1
WO 2014177771 A1
09 March 2016
21 April 2016
06 November 2014
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Netherlands
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
19 May 2017
Date of mailing of the international search report:
29 May 2017
Authorized officer:
Jakobs, Andreas
Top    Part 1: 1 2 3 4 5 6         Part 2: A B C D E