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1. (WO2017136805) COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF AGE-RELATED MACULAR DEGENERATION
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/136805 International Application No.: PCT/US2017/016655
Publication Date: 10.08.2017 International Filing Date: 06.02.2017
IPC:
A61K 31/22 (2006.01) ,A61K 36/73 (2006.01) ,A61K 31/675 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
21
Esters, e.g. nitroglycerine, selenocyanates
215
of carboxylic acids
22
of acyclic acids, e.g. pravastatin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36
Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18
Magnoliophyta (angiosperms)
185
Magnoliopsida (dicotyledons)
73
Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
66
Phosphorus compounds
675
having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
Applicants:
GEORGETOWN UNIVERSITY [US/US]; 37th & O Streets, NW Washington, DC 20057, US
Inventors:
GOLESTANEH, Nady; US
Agent:
BUCK, Todd, B.; US
Priority Data:
62/292,26706.02.2016US
Title (EN) COMPOSITIONS AND METHODS FOR THE DIAGNOSIS AND TREATMENT OF AGE-RELATED MACULAR DEGENERATION
(FR) COMPOSITIONS ET MÉTHODES POUR LE DIAGNOSTIC ET LE TRAITEMENT DE LA DÉGÉNÉRESCENCE MACULAIRE LIÉE À L'ÂGE
Abstract:
(EN) The present invention is related to diagnostic, treatment and compound screening methods related to dry age-related macular degeneration (dry AM D). In select embodiments, the methods comprise determining expression or activity levels of NAD-dependent deacetylase sirtuin-1 (SI RT-1), AM P-activated protein kinase (AM PK), poly(adenosine diphosphate ribose) polymerase-2 (PARP2), peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC-Ια) and/or mRNA levels of RAC-gamma serine/threonine-protein kinase (AKT3). In general, higher levels of PARP2, lower levels of PGC-Ια or AKT3 and/or higher acetylation levels of PGC-Ια in the samples are indicative that the subject or cells from which the samples are obtained are susceptible or are suffering from dry AMD.
(FR) La présente invention concerne le diagnostic, le traitement et des méthodes de criblage de composés, en relation avec la dégénérescence maculaire liée à l'âge sèche (DMLA sèche). Dans certains modes de réalisation, les méthodes comprennent la détermination des niveaux d'expression ou d'activité de la sirtuine-1 (SI RT-1), une désacétylase dépendante du NAD, de la protéine kinase activée par l'AMP (AMPK), de la poly(adénosine diphosphate ribose) polymérase-2 (PARP2), du coactivateur 1-alpha du récepteur gamma activé par les proliférateurs des peroxisomes (PGC-1α), et/ou des niveaux d'ARNm de la RAC sérine/thréonine protéine kinase gamma (AKT3). En général, une augmentation des niveaux de PARP2, une diminution des niveaux de PGC-1α ou de AKT3 et/ou une augmentation du degré d'acétylation du PGC-1α dans des échantillons indiquent que le patient ou les cellules à partir desquels les échantillons sont obtenus sont susceptibles d'être atteints, ou sont atteints, de DMLA sèche.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
US20190049465