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1. (WO2017136792) BACTERIA ENGINEERED TO TREAT DISEASES THAT BENEFIT FROM REDUCED GUT INFLAMMATION AND/OR TIGHTENED GUT MUCOSAL BARRIER
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/136792 International Application No.: PCT/US2017/016603
Publication Date: 10.08.2017 International Filing Date: 03.02.2017
IPC:
A61K 35/74 (2015.01) ,C12N 15/70 (2006.01) ,C12N 15/74 (2006.01) ,C12P 7/52 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
66
Materials from micro-organisms
74
Bacteria
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
70
Vectors or expression systems specially adapted for E. coli
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
74
Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
7
Preparation of oxygen-containing organic compounds
40
containing a carboxyl group
52
Propionic acid; Butyric acids
Applicants:
SYNLOGIC OPERATING COMPANY, INC. [US/US]; 301 Binney Street, Suite 402 Cambridge, MA 02142, US
Inventors:
MILLER, Paul, F.; US
ISABELLA, Vincent, M.; US
KOTULA, Jonathan, W.; US
FALB, Dean; US
FISHER, Adam, B.; US
MILLET, Yves; US
LI, Ning; US
Agent:
HANLEY, Elizabeth, A.; US
ACETO, Donato; US
BOWLES, Anita, M.; US
BARBIC, Andrej; US
BAI, Mei; US
Priority Data:
15/260,31908.09.2016US
62/291,46104.02.2016US
62/291,46804.02.2016US
62/291,47004.02.2016US
62/347,50808.06.2016US
62/347,57608.06.2016US
62/348,62010.06.2016US
62/354,68224.06.2016US
62/362,95415.07.2016US
62/385,23508.09.2016US
62/423,17016.11.2016US
62/439,87128.12.2016US
PCT/US2016/02053002.03.2016US
PCT/US2016/03256513.05.2016US
PCT/US2016/03944424.06.2016US
PCT/US2016/05083608.09.2016US
PCT/US2016/06905228.12.2016US
Title (EN) BACTERIA ENGINEERED TO TREAT DISEASES THAT BENEFIT FROM REDUCED GUT INFLAMMATION AND/OR TIGHTENED GUT MUCOSAL BARRIER
(FR) BACTÉRIES MODIFIÉES POUR TRAITER DES MALADIES POUR LESQUELLES UNE DIMINUTION DE L'INFLAMMATION INTESTINALE ET/OU UNE PLUS GRANDE IMPERMÉABILITÉ DE LA MUQUEUSE INTESTINALE S'AVÈRENT BÉNÉFIQUES
Abstract:
(EN) Genetically engineered bacteria, pharmaceutical compositions thereof, and methods of treating or preventing autoimmune disorders, inhibiting inflammatory mechanisms in the gut, and/or tightening gut mucosal barrier function are disclosed.
(FR) Des bactéries génétiquement modifiées, des compositions pharmaceutiques les comprenant ainsi que des méthodes de traitement ou de prévention de troubles auto-immuns, de l'inhibition de mécanismes inflammatoires dans l'intestin, et/ou de renforcement de la fonction de barrière de la muqueuse intestinale sont divulguées.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
AU2017213646CA3013770EP3411051