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1. (WO2017136769) PEPTIDE DRUG CONJUGATES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/136769 International Application No.: PCT/US2017/016575
Publication Date: 10.08.2017 International Filing Date: 03.02.2017
IPC:
A61P 35/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
EISAI R&D MANAGEMENT CO., LTD. [JP/JP]; 6-10, Koishikawa 4-Chome Bunkyo-ku Tokyo, 112-8088, JP
Inventors:
MCGONIGLE, Sharon; US
MAJUMDER, Utpal; US
CUSTAR, Daniel W.; US
WU, Jiayi; US
POSTEMA, Maarten H.D.; US
Agent:
WALTERS, Todd R.; US
STEWART, Duane A., III; US
MARKOWSKI, Mythili; US
Priority Data:
62/291,27004.02.2016US
Title (EN) PEPTIDE DRUG CONJUGATES
(FR) CONJUGUÉS PEPTIDES-MÉDICAMENTS
Abstract:
(EN) Embodiments provide protein-drug conjugates for treatment of cancer. Protein-drug conjugates may include protein-drug conjugates of Formula I: Ctx-L-Cp (I) or a pharmaceutically acceptable salt or solvate thereof, wherein: Ctx is chlorotoxin or a chlorotoxin analog; Cp is a cryptophycin amide, and L is a linker wherein the linker is bound to Ctx at an X2 moiety of the linker and at one of a lysine residue and the N-terminus of the chlorotoxin or chlorotoxin analog.
(FR) Selon certains modes de réalisation, la présente invention concerne des conjugués protéines-médicaments pour le traitement du cancer. Des conjugués protéines-médicaments peuvent comprendre des conjugués protéines-médicaments de Formule I: Ctx-L-Cp (I) ou un sel ou solvate pharmaceutiquement acceptable de celui-ci, dans laquelle: Ctx est la chlorotoxine ou un analogue de chlorotoxine; Cp est un amide de cryptophycine, et L est un lieur, le lieur étant lié à Ctx au niveau d'une fraction X2 du lieur et au niveau d'un résidu lysine et de l'extrémité N-terminale de la chlorotoxine ou de l'analogue de chlorotoxine.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)