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1. (WO2017136760) COMPOSITIONS AND METHODS OF USING HisGTG TRANSFER RNAS (tRNAs)
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/136760 International Application No.: PCT/US2017/016560
Publication Date: 10.08.2017 International Filing Date: 03.02.2017
IPC:
C12Q 1/68 (2006.01) ,C12N 15/113 (2010.01) ,G01N 33/50 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
113
Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
Applicants:
THOMAS JEFFERSON UNIVERSITY [US/US]; Innovation Pillar 901 Walnut Street 11th Floor Philadelphia, Pennsylvania 19107, US
Inventors:
RIGOUTSOS, Isidore; US
Agent:
DOYLE, Kathryn; US
DRISCOLL, Stephen J.; US
EDDE, Chantal; US
LANDRY, Brian; US
SILVA, Domingos J.; US
SIMPSON, Mark D.; US
MANAS, Michael; US
CROTTY, Justin; US
ZHOU, Weiguo; US
Priority Data:
62/292,03605.02.2016US
Title (EN) COMPOSITIONS AND METHODS OF USING HisGTG TRANSFER RNAS (tRNAs)
(FR) COMPOSITIONS ET MÉTHODES D'UTILISATION D'ARN DE TRANSFERT HisGTG (ARNt)
Abstract:
(EN) The present invention includes a method for analyzing tRNAHisGTG fragments. In one aspect, the present invention includes a method of identifying a subject in need of therapeutic intervention to treat and/or prevent a disease or condition, disease recurrence, or disease progression comprises characterizing the identity of tRNAHisGTG fragments. The invention further includes diagnosing, identifying or monitoring a disease or condition, a panel of engineered oligonucleotides, a kit for a high-throughput assay, and a method and system for identifying tRNAHisGTG fragments.
(FR) La présente invention concerne une méthode permettant d'analyser des fragments d'HisGTG d'ARNt. Selon un aspect, la présente invention concerne une méthode d'identification d'un sujet ayant besoin d'une intervention thérapeutique pour traiter et/ou prévenir une maladie ou un état pathologique, la récidive d'une maladie, ou l'évolution d'une maladie qui comprend la caractérisation de l'identité de fragments d'HisGTG d'ARNt. L'invention concerne en outre le diagnostic, l'identification ou la surveillance d'une maladie ou d'un état pathologique, un ensemble d'oligonucléotides modifiés, un kit pour un dosage à haut débit, et une méthode et un système permettant d'identifier des fragments d'HisGTG d'ARNt.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)