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1. WO2017136739 - GLUCOSE CONJUGATES OF TRIPTOLIDE, ANALOGS AND USES THEREOF

Publication Number WO/2017/136739
Publication Date 10.08.2017
International Application No. PCT/US2017/016527
International Filing Date 03.02.2017
IPC
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 37/06 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
06Immunosuppressants, e.g. drugs for graft rejection
C07D 493/22 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
493Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
22in which the condensed system contains four or more hetero rings
CPC
A61K 31/365
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
365Lactones
A61K 47/549
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
54the modifying agent being an organic compound
549Sugars, nucleosides, nucleotides or nucleic acids
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07D 493/22
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
493Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
22in which the condensed system contains four or more hetero rings
C07H 15/26
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
15Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
26Acyclic or carbocyclic radicals, substituted by hetero rings
C07J 73/003
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
JSTEROIDS
73Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
001by one hetero atom
003by oxygen as hetero atom
Applicants
  • THE JOHNS HOPKINS UNIVERSITY [US]/[US]
Inventors
  • LIU, Jun
  • HE, Qingli
  • POMPER, Martin, G.
  • MINN, Ii
  • YU, Biao
  • WANG, Qiaoling
Agents
  • LIMBACH, Alan, A.
  • HWANG, Pamela, E.
  • HIERHOLZER, Matthew, J.
  • BLAKE, Jackson
  • HAILE, Lisa, A.
Priority Data
62/291,41604.02.2016US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) GLUCOSE CONJUGATES OF TRIPTOLIDE, ANALOGS AND USES THEREOF
(FR) CONJUGUÉS GLUCOSE DE TRIPTOLIDE, ANALOGUES ET UTILISATIONS CORRESPONDANTS
Abstract
(EN)
Provided are compounds generated by conjugation of triptolide with glucose to form glucose-triptolide conjugates, provides compounds with effective anti -proliferative activity and improved tolerability as compared to naturally occurring triptolide compounds.
(FR)
L'invention concerne des composés générés par la conjugaison de triptolide avec du glucose pour former des conjugués glucose-triptolide qui permet d’obtenir des composés présentant une action antiproliférative et une tolérance améliorée par rapport aux composés triptolides naturels.
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