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1. (WO2017136700) NON-NUTRITIVE SWEETENERS AND POLYOLS AS IMAGING AGENTS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/136700 International Application No.: PCT/US2017/016473
Publication Date: 10.08.2017 International Filing Date: 03.02.2017
IPC:
A23L 27/30 (2016.01) ,A61B 5/055 (2006.01) ,A61B 6/03 (2006.01) ,A61K 49/06 (2006.01) ,A61K 49/10 (2006.01)
[IPC code unknown for A23L 27/30]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
B
DIAGNOSIS; SURGERY; IDENTIFICATION
5
Measuring for diagnostic purposes; Identification of persons
05
Measuring for diagnosis by means of electric currents or magnetic fields
055
involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
B
DIAGNOSIS; SURGERY; IDENTIFICATION
6
Apparatus for radiation diagnosis, e.g. combined with radiation therapy equipment
02
Devices for diagnosis sequentially in different planes; Stereoscopic radiation diagnosis
03
Computerised tomographs
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49
Preparations for testing in vivo
06
Nuclear magnetic resonance (NMR) contrast preparations; Magnetic resonance imaging (MRI) contrast preparations
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49
Preparations for testing in vivo
06
Nuclear magnetic resonance (NMR) contrast preparations; Magnetic resonance imaging (MRI) contrast preparations
08
characterised by the carrier
10
Organic compounds
Applicants:
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA [US/US]; 3160 Chestnut Street, Suite 200 Philadelphia, PA 19104, US
SIDRA MEDICAL AND RESEARCH CENTER [QA/QA]; P.O. Box 26999 Doha, QA
Inventors:
MARINCOLA, Francesco, M.; US
REDDY, Ravinder; US
HARIS, Mohammad; QA
HARIHARAN, Hari; US
BAGGA, Puneet; US
SCHNALL, Mitchell, D.; US
Agent:
PALOVICH, Tracy, U.; US
Priority Data:
62/291,94905.02.2016US
Title (EN) NON-NUTRITIVE SWEETENERS AND POLYOLS AS IMAGING AGENTS
(FR) ÉDULCORANTS NON NUTRITIFS ET POLYOLS UTILISÉS COMME AGENTS D'IMAGERIE
Abstract:
(EN) The present disclosure relates to magnetic resonance imaging (MRI) methods comprising (i) obtaining a baseline chemical exchange saturation transfer (CEST) MRI image of a patient, (ii) administering an effective amount of a non-nutritive sweetener to the patient, and (iii) obtaining one or more test CEST MRI image of the patient subsequent to the administering step (ii); wherein the step (i) and (iii) acquisition parameters are substantially the same. The non- nutritive sweetener may include a natural or artificial sugar alcohol, polyol, or combinations or derivatives thereof.
(FR) La présente invention concerne des procédés d'imagerie par résonance magnétique (IRM) consistant (i) à obtenir une image par IRM de transfert de saturation par échange chimique (CEST) de ligne de base d'un patient, (ii) à administrer au patient une quantité efficace d'un édulcorant non nutritif, et (iii) à obtenir une ou plusieurs images d'analyse par IRM CEST du patient après l'étape d'administration (ii) ; les paramètres d'acquisition des étapes (i) et (iii) étant sensiblement identiques. L'édulcorant non nutritif peut comprendre un alcool de sucre naturel ou artificiel, un polyol ou des combinaisons ou des dérivés de ceux-ci.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
US20180369427