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1. (WO2017136556) COMPOSITIONS AND METHODS FOR TREATING INFECTIONS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/136556 International Application No.: PCT/US2017/016224
Publication Date: 10.08.2017 International Filing Date: 02.02.2017
IPC:
C07D 401/04 (2006.01) ,C07D 403/04 (2006.01) ,C07D 403/14 (2006.01) ,A61K 31/506 (2006.01) ,A61P 33/02 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
14
containing three or more hetero rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
506
not condensed and containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
33
Antiparasitic agents
02
Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
Applicants:
VYERA PHARMACEUTICALS, LLC [US/US]; 600 Third Avenue 10th Floor New York, NY 10016, US
Inventors:
THOMAS, Stephen; US
HOPPER, Allen, T.; US
WELSCH, Mathew; US
Agent:
ABELLEIRA, Susan, M.; US
BLOUNT, Jennifer, V.; US
AKHIEZER, Alexander; US
CHOI, Philip, S.; US
HALSTEAD, David, P.; US
Priority Data:
62/291,90005.02.2016US
62/375,71216.08.2016US
Title (EN) COMPOSITIONS AND METHODS FOR TREATING INFECTIONS
(FR) COMPOSITIONS ET MÉTHODES DE TRAITEMENT D'INFECTIONS BACTÉRIENNES
Abstract:
(EN) The invention relates to inhibitors of dihydrotolate reductase and pharmaceutical preparations thereof. The invention further relates to methods of treatment of parasitic infections, such as T. gondii, T. cruzi, P. falciparum, T. hrucei, or L. major infections, using the novel inhibitors of the invention.
(FR) L'invention concerne des inhibiteurs de la dihydrotolate réductase et leurs préparations pharmaceutiques. L'invention concerne en outre des méthodes de traitement d'infections parasitaires, telles que les infections par T. gondii, T. cruzi, P. falciparum, T. brucei, ou L. major, utilisant les nouveaux inhibiteurs de l'invention.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
MYPI 2018001390AU2017213824SG11201806620TCA3013760KR1020180119590ID2018/12610
EP3411367IL260952CN109071486BR112018015924IN201827030888EA201891766
US20190077794PH1/2018/501646