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1. (WO2017136466) HEME PROTEIN CATALYSTS FOR CARBON-SILICON BOND FORMATION IN VITRO AND IN VIVO
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2017/136466 International Application No.: PCT/US2017/016083
Publication Date: 10.08.2017 International Filing Date: 01.02.2017
IPC:
C12P 13/00 (2006.01) ,C07F 7/08 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
13
Preparation of nitrogen-containing organic compounds
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
7
Compounds containing elements of the 4th Group of the Periodic System
02
Silicon compounds
08
Compounds having one or more C-Si linkages
Applicants:
CALIFORNIA INSTITUTE OF TECHNOLOGY [US/US]; Office of Technology Transfer 1200 East California Boulevard MC 210-85 Pasadena, California 91125, US
Inventors:
KAN, Sek Bik Jennifer; US
LEWIS, Russell D.; US
CHEN, Kai; US
ARNOLD, Frances H.; US
Agent:
ROBERTS, Byron; US
PRESLEY, Andrew D.; US
SNYDER, Joseph R.; US
MATHISON, Mark P.; US
TRIMBLE, Alexander R.; US
Priority Data:
62/290,21102.02.2016US
62/365,79722.07.2016US
62/409,13717.10.2016US
Title (EN) HEME PROTEIN CATALYSTS FOR CARBON-SILICON BOND FORMATION IN VITRO AND IN VIVO
(FR) CATALYSEURS DE PROTÉINES À HÈMES POUR LA FORMATION D'UNE LIAISON CARBONE-SILICIUM IN VITRO ET IN VIVO
Abstract:
(EN) The present invention provides compositions and methods for catalyzing the formation of carbon-silicon bonds using heme proteins. In certain aspects, the present invention provides heme proteins, including variants and fragments thereof, that are capable of carrying out in vitro and in vivo carbene insertion reactions for the formation of carbon-silicon bonds. In other aspects, the present invention provides methods for producing an organosilicon product, the method comprising providing a silicon-containing reagent, a carbene precursor, and a heme protein; and combining the components under conditions sufficient to produce an organosilicon product. Host cells expressing the heme proteins are also provided by the present invention.
(FR) La présente invention concerne des compositions et des procédés permettant de catalyser la formation de liaisons carbone-silicium à l'aide de protéines à hèmes. Selon certains aspects, la présente invention concerne des protéines à hèmes, comprenant des variants et des fragments de ceux-ci, qui sont capables de réaliser in vitro et in vivo des réactions d'insertion de carbène pour la formation de liaisons carbone-silicium. Selon d'autres aspects, la présente invention concerne des procédés de production d'un produit d'organosilicium, le procédé consistant à utiliser un réactif contenant du silicium, un précurseur de carbène, et une protéine à hème ; et à mélanger les constituants dans des conditions suffisantes pour produire un produit d'organosilicium. L'invention concerne également des cellules hôtes exprimant les protéines à hèmes.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)